Hariharan H, Barnum D A, Mitchell W R
Can J Comp Med. 1974 Jul;38(3):213-21.
Prevalence of antimicrobial drug resistance among over 3000 clinical isolates of animal pathogens in Ontario during 1971-72 has been studied. A high number of multiple resistance patterns is prevalent among members of Enterobacteriaceae, especially Escherichia coli and Salmonella typhimurium. The most common resistance pattern among bovine strains was against not less than six drugs in common use. Among different animal species the bovine population was found to be the source of a high percentage of chloramphenicol resistant E. coli and S. typhimurium organisms. All the isolates resistant to this drug were in addition resistant to three or more other antibiotics of established therapeutic value. All the multiple resistant isolates of S. typhimurium tested had R factors and they transferred most of the resistance determinants including that for chloramphenicol to a recipient E. coli in vitro.Penicillin resistance among Staphylococcus aureus of bovine mammary origin did not appear to be high. Antimicrobial drug susceptibility patterns of staphylococci, streptococci and Corynebacterium sp indicate effective in vitro activity with many antimicrobial agents.
对1971 - 1972年安大略省3000多株动物病原体临床分离株中的抗菌药物耐药性进行了研究。肠杆菌科成员中，尤其是大肠杆菌和鼠伤寒沙门氏菌，存在大量多重耐药模式。牛源菌株中最常见的耐药模式是对不少于六种常用药物耐药。在不同动物物种中，牛群被发现是耐氯霉素大肠杆菌和鼠伤寒沙门氏菌的高比例来源。所有对该药物耐药的分离株还对三种或更多其他具有既定治疗价值的抗生素耐药。所有测试的多重耐药鼠伤寒沙门氏菌分离株都有R因子，并且它们在体外将大部分耐药决定簇，包括氯霉素耐药决定簇，转移给了受体大肠杆菌。牛乳腺源金黄色葡萄球菌中的青霉素耐药性似乎不高。葡萄球菌、链球菌和棒状杆菌属的抗菌药物敏感性模式表明，许多抗菌剂在体外具有有效的活性。
