Presidente P J, McCraw B M, Lumsden J H
Can J Comp Med. 1980 Oct;44(4):423-32.
The pathogenesis of early prepatent Fascioloides magna infection was investigated in seven fawns (Odocoileus virginianus) given 500 metacercariae and examined at one, two, three, five, eight, 12 and 13 weeks postinoculation. Blood samples were taken from eight inoculated deer every two weeks up to 16 weeks postinoculation. Eosinophilia with a mild transitory anemia were the main clincopathological features. Postmortem examination at two weeks postinoculation revealed extensive migration of immature flukes. Subcapsular tracks in the liver, nodules on the blind sacs of the rumen, as well as retroperitoneal granulomas on flanks and necrotic tracks on the diaphragm were found. Evidence of penetration of flukes into the lung was found at two weeks postinoculation and there was early granuloma formation at three weeks postinoculation. Flukes migrating into tissues other than the liver were destroyed in large granulomas, although remnants of degenerating parasites were not found. At eight weeks postinoculation, widespread granuloma formation characterized the infection with this lesion present in nodes along the gastrointestinal tract, in the mesentery, flanks, psoas muscles, diaphragm, between the ribs and in the lungs. By 12 weeks postinoculation subcapsular tracks were observed in the liver.
研究了7只接种500个肝片吸虫囊蚴的小鹿（弗吉尼亚白尾鹿）早期潜在肝片吸虫感染的发病机制，并在接种后1、2、3、5、8、12和13周进行检查。在接种后长达16周的时间里，每两周从8只接种的鹿身上采集血样。嗜酸性粒细胞增多伴轻度短暂性贫血是主要的临床病理特征。接种后两周的尸检显示未成熟吸虫广泛移行。在肝脏发现包膜下轨迹，在瘤胃盲囊发现结节，在胁腹发现腹膜后肉芽肿，在膈肌发现坏死轨迹。接种后两周发现吸虫侵入肺部的证据，接种后三周出现早期肉芽肿形成。尽管未发现退化寄生虫的残余物，但迁移到肝脏以外组织的吸虫在大的肉芽肿中被破坏。接种后八周，广泛的肉芽肿形成是感染的特征，这种病变出现在沿胃肠道的淋巴结、肠系膜、胁腹、腰大肌、膈肌、肋骨间和肺部。接种后12周，在肝脏观察到包膜下轨迹。
