将药物植入大鼠腹侧丘脑后大鼠的强迫性啃咬行为。对吗啡作用机制的一种探讨。
Compulsive gnawing in rats after implantation of drugs into the ventral thalamus. A contribution to the mechanism of morphine action.
作者信息
Bergmann F, Chaimovitz M, Pasternak V, Ramu A
出版信息
Br J Pharmacol. 1974 Jun;51(2):197-205. doi: 10.1111/j.1476-5381.1974.tb09647.x.
1 Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses.2 Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.3 The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with alpha-methyltyrosine methyl ester or alpha-methyldopa prevents only the gnawing response to morphine, but not to apomorphine.4 Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine.5 Systemic amphetamine potentiates the effect of thalamic deposits of morphine.6 Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines.
将吗啡植入大鼠纹状体的各个部位只会引起微弱的啃咬反应。
在丘脑腹侧核区域注射阿扑吗啡、吗啡或美沙酮会产生双相反应，即全身兴奋，随后是一段强烈的啃咬期。
阿扑吗啡和吗啡的作用均被氯丙嗪、氟哌啶醇和匹莫齐特阻断。然而，用α-甲基酪氨酸甲酯或α-甲基多巴预处理仅能阻止对吗啡的啃咬反应，而不能阻止对阿扑吗啡的啃咬反应。
全身注射纳洛啡、吗啡或哌替啶可抑制由丘脑植入阿扑吗啡或吗啡所引起的啃咬反应。
全身注射苯丙胺可增强丘脑注射吗啡的效果。
将吗啡植入丘脑腹侧区域后出现的强迫性啃咬，可能是由于儿茶酚胺的产生和释放增加所致。
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