Freise J, Hofmann R, Gebel M, Huchzermeyer H
Endoscopy. 1979 Feb;11(1):13-7. doi: 10.1055/s-0028-1098317.
Chronic gastric erosions were detected with a frequency of 4.4% in 8,468 patients over the six year period from 1971 to 1977. The lesions were usually multiple, chain-like or clustered, along the greater curvature. The age group most often afflicted was the 50-60 year olds, and male predominance were three to one. In one-third of the cases, chronic erosions were found in combination with gastric or duodenal ulceration. Longterm observation of 64 patients over a period of four and a half years revealed no change in the condition in 50%, increase, decrease or complete disappearance of the lesions were found in the remaining 50%. In 10% chain-like multiple erosions developed into a persisting fold in the gastric mucosa. No evidence suggesting that erosive lesions lead to chronic ulceration or development of either polyps or malignancy within 4 1/2 years was recorded, nor was there any association with gastric protein loss.
在1971年至1977年的六年期间,对8468名患者进行检查,发现慢性胃糜烂的发生率为4.4%。病变通常为多发,沿胃大弯呈链状或簇状分布。最常受累的年龄组为50至60岁,男性与女性的比例为3比1。三分之一的病例中,慢性糜烂与胃溃疡或十二指肠溃疡同时存在。对64名患者进行了四年半的长期观察,发现50%的患者病情无变化,其余50%的患者病变有增加、减少或完全消失的情况。10%的链状多发糜烂发展为胃黏膜的持续性皱襞。在4年半的时间里,没有证据表明糜烂性病变会导致慢性溃疡、息肉或恶性肿瘤的发生,也没有发现与胃蛋白丢失有关。