橡胶促进剂二硫化四甲基秋兰姆（TMTD）和巯基苯并噻唑（MBT）的致敏作用

[The allergenic effect of rubber accelerators tetramethyl thiuram disulfide (TMTD) and mercaptobenzothiazole (MBT)].

作者信息

Ziegler V, Süss E

出版信息

Allerg Immunol (Leipz). 1974;20-21(3):281-5.

Abstract

The eczematogenic effects of tetramethylthiuramidsulfid and of mercaptobenzothiazol were studied on the basis of an inquiry in establishments using TMTD and MBT, a frequency analysis of positive reactions of our standard series in 1971 and testing of various rubber articles on sensitized persons as well as animal experiments. The results indicate a wider use, a higher percentage of positive epicutaneous tests and also a higher sensitizing potency in the animal test of the TMTD as compared with MBT. MBT was removed from our standard series.

摘要

基于对使用二硫化四甲基秋兰姆（TMTD）和巯基苯并噻唑（MBT）的企业的调查、1971年我们标准系列阳性反应的频率分析、对致敏者各种橡胶制品的测试以及动物实验，研究了二硫化四甲基秋兰姆和巯基苯并噻唑的致湿疹作用。结果表明，与MBT相比，TMTD在动物试验中的应用范围更广、皮上试验阳性百分比更高，致敏能力也更强。MBT已从我们的标准系列中移除。