Horlick L
J Lipid Res. 1966 Jan;7(1):116-21.
AY 9944 is a novel inhibitor of cholesterol biosynthesis which appears to act on the Delta 7-reductase enzyme, interfering with the conversion of 7-dehydrocholesterol to cholesterol. In all tissues studied, with the exception of the lens, there was a reduction in cholesterol and a marked accumulation of 7-dehydrocholesterol. Isotope studies showed a reduced uptake of acetate into cholesterol, and an increased uptake into 7-dehydrocholesterol, in various tissues in vivo and by skin samples in vitro. There was no apparent accumulation of lanosterol or of the methostenols in the rat skin.
AY 9944是一种新型胆固醇生物合成抑制剂，它似乎作用于Δ7-还原酶，干扰7-脱氢胆固醇向胆固醇的转化。在所有研究的组织中，除晶状体外，胆固醇含量均降低，7-脱氢胆固醇显著积累。同位素研究表明，在体内各种组织以及体外皮肤样本中，乙酸盐摄取到胆固醇中的量减少，而摄取到7-脱氢胆固醇中的量增加。大鼠皮肤中未出现羊毛甾醇或甲戊烯醇的明显积累。
