影响脂质代谢的药物。28. 一种7-脱氢胆固醇δ-7-还原酶抑制剂（AY-9944）作为δ-7-甾醇代谢研究的工具。 - Suppr

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超能文献

Agents affecting lipid metabolism. 28. A 7-dehydrocholesterol delta-7-reductase inhibitor (AY-9944) as tool in studies of delta-7-sterol metabolism.

作者信息

Dvornik D, Kraml M, Bagli J F

出版信息

Biochemistry. 1966 Mar;5(3):1060-4. doi: 10.1021/bi00867a035.

DOI:10.1021/bi00867a035

PMID:5911284

Abstract

摘要

相似文献

Agents affecting lipid metabolism. 28. A 7-dehydrocholesterol delta-7-reductase inhibitor (AY-9944) as tool in studies of delta-7-sterol metabolism.影响脂质代谢的药物。28. 一种7-脱氢胆固醇δ-7-还原酶抑制剂（AY-9944）作为δ-7-甾醇代谢研究的工具。

Biochemistry. 1966 Mar;5(3):1060-4. doi: 10.1021/bi00867a035.

Studies on the inhibitory mechanism of some hypocholesterolemic agents on 7-dehydrocholesterol delta-7-bond reductase activity.某些降胆固醇药物对7-脱氢胆固醇δ-7-键还原酶活性的抑制机制研究。

Biochim Biophys Acta. 1965 Jun 1;98(3):624-31. doi: 10.1016/0005-2760(65)90160-8.

The effect of alpha-methyl gamma-phenyl butyric acid on sterol biosynthesis in vitro.α-甲基-γ-苯基丁酸对体外甾醇生物合成的影响

Biochem Pharmacol. 1969 Mar;18(3):625-31. doi: 10.1016/0006-2952(69)90087-2.

Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. I. Zuclomiphene.

Biochem Pharmacol. 1977 Jun 15;26(12):1161-7. doi: 10.1016/0006-2952(77)90062-4.

Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. II. AY-9944 and AY-9944 plus zuclomiphene.降胆固醇药物对中枢神经系统胆固醇生物合成的影响。II. AY - 9944及AY - 9944加氯米芬。

Biochem Pharmacol. 1977 Jun 15;26(12):1169-73. doi: 10.1016/0006-2952(77)90063-6.

Repeated estimation of liver cholesterol synthesis in vivo, using the inhibitor AY-9944.使用抑制剂AY - 9944在体内重复估计肝脏胆固醇合成。

Biochim Biophys Acta. 1971 Sep 1;239(3):475-81. doi: 10.1016/0005-2760(71)90039-7.

Source of cholesterol for the ocular lens, studied with U18666A: a cataract-producing inhibitor of lipid metabolism.

Exp Eye Res. 1983 Jul;37(1):33-43. doi: 10.1016/0014-4835(83)90147-1.

Regulation of steroidogenesis by ubiquinone.泛醌对类固醇生成的调节作用。

Biochem Biophys Res Commun. 1967 May 25;27(4):474-8. doi: 10.1016/s0006-291x(67)80009-3.

Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the rat.一种新型胆固醇生物合成抑制剂（AY 9944）对大鼠血清和组织甾醇的影响。

J Lipid Res. 1966 Jan;7(1):116-21.

Site of the in vitro inhibition of cholesterol biosynthesis by tolbutamide and phenethylbiguanide.

Biochemistry. 1965 Jun;4(6):1138-43. doi: 10.1021/bi00882a023.

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Oxysterols and Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome: Implications for an Improved Therapeutic Intervention.氧化固醇与 Smith-Lemli-Opitz 综合征大鼠模型中的视网膜变性：改善治疗干预的意义。

Molecules. 2018 Oct 22;23(10):2720. doi: 10.3390/molecules23102720.

Agents affecting lipid metabolism. XXVI. Specificity of some inhibitors of the late stages of cholesterol biosynthesis.影响脂质代谢的药物。二十六。胆固醇生物合成后期某些抑制剂的特异性。

Lipids. 1967 Jan;2(1):5-7. doi: 10.1007/BF02531992.

The effect of AY-9944 on yeast sterol and sterol ester metabolism.AY-9944对酵母甾醇和甾醇酯代谢的影响。

Lipids. 1983 Aug;18(8):545-52. doi: 10.1007/BF02535395.

The stereochemistry of the hydrogen elimination in the biological conversion of cholest-7-en-3-beta-ol into cholesterol.胆甾-7-烯-3-β-醇生物转化为胆固醇过程中氢消除的立体化学。

Biochem J. 1967 Feb;102(2):462-7. doi: 10.1042/bj1020462.

The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.7-脱氢胆固醇的生物转化及关于双键还原的评论

Biochem J. 1968 Feb;106(4):803-10. doi: 10.1042/bj1060803.

The obligatory intermediacy of a cholesta-5,7-diene system in the hepatic biosynthesis of cholesterol.在肝脏胆固醇生物合成中胆甾-5,7-二烯系统的必需中间作用。

Biochem J. 1966 Nov;101(2):23C-25C. doi: 10.1042/bj1010023c.

Inhibition of enzymatic reduction of delta 14-double bond of 5 alpha-cholesta-8,14-dien-3 beta-ol and 5 alpha-cholesta-7,14-dien-3 beta-ol by AY-9944.AY-9944对5α-胆甾-8,14-二烯-3β-醇和5α-胆甾-7,14-二烯-3β-醇δ14-双键酶促还原反应的抑制作用

Lipids. 1975 Jan;10(1):9-11. doi: 10.1007/BF02532186.

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