Bekierkunst A
Science. 1966 Apr 22;152(3721):525-6. doi: 10.1126/science.152.3721.525.
There is a decrease in the content of nicotinamide-adenine dinucleotide of tubercle bacilli grown in the presence of isoniazid. In extracts of tubercle bacilli, the activity of nicotinamide-adenine dinucleotidase is nil or very small; after incubation with the drug the enzyme becomes active. Isoniazid also increases the activity of the enzyme after it is partially activated by heating. There may be a correlation between the capacity of isoniazid to activate the enzyme and the decrease in the dinucleotide content of the tubercle bacilli.
在异烟肼存在的情况下生长的结核杆菌中，烟酰胺腺嘌呤二核苷酸的含量会降低。在结核杆菌提取物中，烟酰胺腺嘌呤二核苷酸酶的活性为零或非常低；与药物孵育后，该酶变得有活性。在通过加热使其部分活化后，异烟肼也会增加该酶的活性。异烟肼激活该酶的能力与结核杆菌中二核苷酸含量的降低之间可能存在关联。
