Nett A E, Gilbert J A
Can Med Assoc J. 1966 Jul 9;95(2):45-9.
A survey was made to determine the incidence and to elucidate the manifestations of primary carcinoma of the liver in Alberta. The findings were compared with other reported series. Ninety-six cases were identified: 69 hepatomas, 25 cholangiomas and two cholangiohepatomas. Seventy-four of the patients were male and 22 were female, a male preponderance of greater than 3:1. Ages ranged from 7 days to 92 years, but the majority of the patients (58%) were in the seventh and eighth decades. The incidence of associated cirrhosis (38.5%) was lower than that noted in most series.Hepatomegaly, abdominal pain, weight loss and ascites were the outstanding clinical features. Gastrointestinal hemorrhage was frequent and second only to hepatic failure as the immediate cause of death. An abdominal mass and pleural effusion occurred in higher frequency than that cited in the literature. Associated disorders included peptic ulceration and cholelithiasis.Surgical biopsy was superior to needle biopsy in establishing the diagnosis. Laboratory tests and routine radiographs may be of diagnostic aid.
为确定艾伯塔省原发性肝癌的发病率并阐明其表现，进行了一项调查。将研究结果与其他已报道的系列进行了比较。共确诊96例：69例肝细胞癌、25例胆管癌和2例胆管肝细胞癌。患者中74例为男性，22例为女性，男性占比超过3:1。年龄范围从7天至92岁，但大多数患者（58%）年龄在七、八十岁。合并肝硬化的发生率（38.5%）低于大多数系列报道。肝肿大、腹痛、体重减轻和腹水是突出的临床特征。胃肠道出血很常见，是仅次于肝衰竭的直接死亡原因。腹部肿块和胸腔积液的发生率高于文献报道。相关疾病包括消化性溃疡和胆石症。在确立诊断方面，手术活检优于针吸活检。实验室检查和常规X线片可能有助于诊断。
