Dardiri A H, Seibold H R, DeLay P D
Can J Comp Med Vet Sci. 1966 Mar;30(3):71-81.
The clinical response to Teschen disease and the excretion and rate of virus distribution in tissues of colostrum-deprived, specific pathogenfree pigs was determined. Severe, mild, and clinically inapparent responses to the disease were noticed following simultaneous intracranial and intranasal infections. Fourteen-day-old pigs reacted more severely to infection than 21-day-old pigs. The virus was detected in feces 2-3 days following infection but not in stools of surviving pigs 30 days after infection. The highest concentration of virus occurred during the incubation period and before onset of paralysis; the lowest concentrations were found during terminal disease stages. In tissues collected before or immediately after death of pigs, Teschen disease virus was found in several visceral organs but not in blood, urine or urinary bladder tissue. Virus yield was highest in brain and spinal cord tissues. Highest virus concentration was found in the cervical thoracic portions of the spinal cord, thalamus and cerebellum. Other aspects of the clinical disease are discussed.
测定了初乳缺乏、无特定病原体猪对泰申病的临床反应以及病毒在组织中的排泄和分布速率。在同时进行颅内和鼻内感染后，观察到了对该病的严重、轻度和临床不明显反应。14日龄仔猪对感染的反应比21日龄仔猪更严重。感染后2 - 3天在粪便中检测到病毒，但感染30天后存活仔猪的粪便中未检测到。病毒浓度在潜伏期和麻痹发作前最高；在疾病末期浓度最低。在猪死亡前或死亡后立即采集的组织中，在几个内脏器官中发现了泰申病病毒，但在血液、尿液或膀胱组织中未发现。脑和脊髓组织中的病毒产量最高。在脊髓颈胸段、丘脑和小脑中发现病毒浓度最高。还讨论了临床疾病的其他方面。
