Hallum J V, Younger J S
J Bacteriol. 1966 Oct;92(4):1047-50. doi: 10.1128/jb.92.4.1047-1050.1966.
Hallum, J. V. (University of Pittsburgh, Pittsburgh, Pa.), and J. S. Youngner. Quantitative aspects of inhibition of virus replication by interferon in chick embryo cell cultures. J. Bacteriol. 92:1047-1050. 1966.-The effect of interferon on single cycles of replication of vesicular stomatitis virus and Mahoney poliovirus ribonucleic acid was studied in chick embryo cell cultures. The results showed that the titer of a given interferon preparation was independent of the input multiplicity of the challenge virus. In addition, the increase in virus yield with increasing virus challenge was a function of the number of infected cells, each of which yielded progeny at a level determined by the concentration of interferon to which the cells were exposed. These findings are not compatible with the concept that increases in the size of the virus challenge reverse or overcome protection of cells by interferon.
哈勒姆，J. V.（匹兹堡大学，宾夕法尼亚州匹兹堡）和J. S. 扬纳。鸡胚细胞培养中干扰素对病毒复制抑制作用的定量研究。《细菌学杂志》92:1047 - 1050。1966年。——在鸡胚细胞培养中研究了干扰素对水疱性口炎病毒和马奥尼脊髓灰质炎病毒核糖核酸单周期复制的影响。结果表明，给定干扰素制剂的效价与攻击病毒的输入复数无关。此外，随着病毒攻击量增加，病毒产量的增加是受感染细胞数量的函数，每个受感染细胞产生子代的水平由细胞所接触的干扰素浓度决定。这些发现与病毒攻击量增加会逆转或克服干扰素对细胞的保护这一概念不相符。
