[我们使用达穆尔和史密斯方法的经验]

[Our experience with the method of D'Amour and Smith].

作者信息

Stefanova D, Ivanov K

出版信息

Eksp Med Morfol. 1975;14(2):110-6.

Abstract

The authors carried out studies on a group of analgetic preparations (morphine, lydol, thylidine, pentazocine and analgine) by the method of D Amour and Smith, using thermic painful stimulation. The experiments were carried out on white rats-young and adult of both sexes of the strain Wistar. The mean lethal dosis were determined as well as the mean effective doses and therapeutic indices. The experimental results showed that thylidine was the strongest analgetic agent with atherapeutic index of 67. The index of morphine was 63 and was close to that of thylidine, but without statistical significance. The remaining analgetic indices were with low indices: lyndiol-with 5, pentazocine - 12 and analgine - 2. The method used, according to our data, could be applied successfully on rats of both sexes, at various age groups and both strains. The method is convenient for testing analgetic activity of preparations from two basic types of analgetic agents-narcotic and nonnarcotic.

摘要

作者采用D·阿莫尔和史密斯的方法，利用热痛刺激，对一组镇痛药（吗啡、利多尔、噻嘧啶、喷他佐辛和安乃近）进行了研究。实验在Wistar品系的年轻和成年雌雄白鼠身上进行。测定了平均致死剂量、平均有效剂量和治疗指数。实验结果表明，噻嘧啶是最强的镇痛药，治疗指数为67。吗啡的指数为63，与噻嘧啶接近，但无统计学意义。其余镇痛药指数较低：利多尔为5，喷他佐辛为12，安乃近为2。根据我们的数据，所使用的方法可成功应用于不同年龄组和两个品系的雌雄大鼠。该方法便于测试两种基本类型镇痛药——麻醉性和非麻醉性镇痛药制剂的镇痛活性。