甲羟戊酸的细菌代谢
Bacterial metabolism of mevalonic acid.
作者信息
Siddiqi M A, Rodwell V W
出版信息
J Bacteriol. 1967 Jan;93(1):207-14. doi: 10.1128/jb.93.1.207-214.1967.
Abstract
Soluble cell-free extracts of actinomycete S4 grown on media containing mevalonate catalyze acetoacetate formation from mevalonate, mevaldate, and beta-hydroxy-beta-methylglutaryl-coenzyme A (CoA). Conversion of mevalonate to acetoacetate involves formation of free beta-hydroxy-beta-methylglutaryl-CoA, but not free mevaldate. The reaction favors mevalonate oxidation, and nicotinamide adenine dinucleotide, rather than nicotinamide adenine dinucleotide phosphate, acts as oxidant.
摘要
在含有甲羟戊酸的培养基上生长的放线菌S4的可溶性无细胞提取物，可催化由甲羟戊酸、甲羟戊酸酯和β-羟基-β-甲基戊二酰辅酶A（CoA）生成乙酰乙酸。甲羟戊酸转化为乙酰乙酸涉及游离β-羟基-β-甲基戊二酰辅酶A的形成，但不涉及游离甲羟戊酸酯的形成。该反应有利于甲羟戊酸的氧化，烟酰胺腺嘌呤二核苷酸而非烟酰胺腺嘌呤二核苷酸磷酸作为氧化剂。
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