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3-羟基-3-甲基戊二酸的细菌代谢

Bacterial metabolism of 3-hydroxy-3-methylglutaric acid.

作者信息

Ahmad N, Siddiqi M

出版信息

J Bacteriol. 1973 Jul;115(1):162-7. doi: 10.1128/jb.115.1.162-167.1973.

DOI:10.1128/jb.115.1.162-167.1973
PMID:4717513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC246226/
Abstract

An organism belonging to Pseudomonadaceae and capable of utilizing 3-hydroxy-3-methylglutarate as sole carbon source has been isolated from soil. Whole-cell preparations catalyze the oxidation of acetoacetate, acetate, glyoxylate, and citric acid cycle intermediates. Cell-free extracts of 3-hydroxy-3-methylglutarate-grown cells show an adenosine triphosphate, coenzyme A (CoA), and Mg(2+)-dependent conversion of 3-hydroxy-3-methylglutarate to 3-hydroxy-3-methylglutaryl-CoA. Succinyl-CoA-generating system has no effect on the activation and catabolism of 3-hydroxy-3-methylglutarate.

摘要

从土壤中分离出一种属于假单胞菌科且能够利用3-羟基-3-甲基戊二酸作为唯一碳源的生物体。全细胞制剂可催化乙酰乙酸、乙酸、乙醛酸和柠檬酸循环中间体的氧化。在以3-羟基-3-甲基戊二酸培养的细胞的无细胞提取物中，3-羟基-3-甲基戊二酸在三磷酸腺苷、辅酶A（CoA）和镁离子的依赖下转化为3-羟基-3-甲基戊二酰辅酶A。琥珀酰辅酶A生成系统对3-羟基-3-甲基戊二酸的激活和分解代谢没有影响。

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本文引用的文献

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Enzymatic synthesis of citric acid. II. Crystalline condensing enzyme.柠檬酸的酶促合成。II. 结晶缩合酶。
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