Silah J G, Strong C G, Nowaczynski W, Genest J
Can Med Assoc J. 1967 May 27;96(21):1397-400.
Forty hypertensive patients were studied to examine the assumption that the angiotensin pressor dose reflects endogenous renin activity. Peripheral renin activity was assayed by the method of Boucher et al.(4) Sensitivity to the infusion of synthetic angiotensin II was determined as suggested by Kaplan and Silah.(1)Sixteen patients with essential hypertension with normal renal angiography required 3.8 ng. angiotensin/kg./min. to raise the diastolic pressure 20 mm. Hg. All but one were sensitive to angiotensin infusion of less than 5 ng./kg./min. Renin activity was normal in all except in one sensitive subject. Angiotensin infusion response and mean renin activity in 13 patients with essential hypertension with abnormal renal angiography were similar to that of the first group. The pressor dose in 11 renovascular hypertensives was 9.8 ng./kg./min. All but three had elevated plasma renin activity.OUR RESULTS SUGGEST THAT: (1) the angiotensin infusion test is suitable for differentiating patients with true renovascular hypertension from those with essential hypertension with or without associated renal artery disease; (2) the angiotensin pressor dose correlates with the level of peripheral venous renin activity (p < 0.01).
对40名高血压患者进行了研究，以检验血管紧张素升压剂量反映内源性肾素活性这一假设。采用Boucher等人的方法(4)测定外周肾素活性。按照Kaplan和Silah的建议(1)确定对合成血管紧张素II输注的敏感性。16名肾血管造影正常的原发性高血压患者需要3.8纳克血管紧张素/千克/分钟才能使舒张压升高20毫米汞柱。除1人外，所有人对低于5纳克/千克/分钟的血管紧张素输注敏感。除1名敏感受试者外，其余所有人的肾素活性均正常。13名肾血管造影异常的原发性高血压患者的血管紧张素输注反应和平均肾素活性与第一组相似。11名肾血管性高血压患者的升压剂量为9.8纳克/千克/分钟。除3人外，所有人的血浆肾素活性均升高。我们的结果表明：(1)血管紧张素输注试验适用于区分真正的肾血管性高血压患者与伴有或不伴有相关肾动脉疾病的原发性高血压患者；(2)血管紧张素升压剂量与外周静脉肾素活性水平相关(p<0.01)。
