邻硝基苯硫基氨基保护基团的简便硫解去除法。
Facile thiolytic removal of the o-nitrophenylsulphenyl amino-protecting group.
作者信息
Stern M, Warshawsky A, Fridkin M
出版信息
Int J Pept Protein Res. 1979 Mar;13(3):315-9. doi: 10.1111/j.1399-3011.1979.tb01885.x.
Abstract
2-Mercaptopyridine was used to effect the selective, mild and efficient cleavage of the o-nitrophenylsulphenyl amino-protecting group from several amino acids and peptides. By utilization of this reagent a stepwise synthesis of the tetrapeptide Thr-Lys-Leu-Arg([Leu3]tuftsin) was successfully achieved. The potential use of 2-mercaptopyridine in mechanized peptide synthesis via the polymeric reagents approach is discussed.
摘要
2-巯基吡啶用于从几种氨基酸和肽中选择性、温和且高效地裂解邻硝基苯硫基氨基保护基团。通过使用该试剂，成功实现了四肽苏氨酸-赖氨酸-亮氨酸-精氨酸（[亮氨酸3]促吞噬肽）的逐步合成。讨论了2-巯基吡啶在通过聚合物试剂方法进行机械化肽合成中的潜在用途。
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