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琼脂存在时的抗生素活性。

Antibiotic activity in the presence of agar.

作者信息

Hanus F J, Sands J G, Bennett E O

出版信息

Appl Microbiol. 1967 Jan;15(1):31-4. doi: 10.1128/am.15.1.31-34.1967.

DOI:10.1128/am.15.1.31-34.1967
PMID:4291669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC546838/
Abstract

Agar has been shown to interfere with the activity of some antibiotics against Staphylococcus aureus. This interference has been observed as an increase in the minimal inhibitory concentration and in the diameter of the zone of inhibition. Purifying the agar with water extractions substantially reduced this adverse effect.

摘要

已证明琼脂会干扰某些抗生素对金黄色葡萄球菌的活性。这种干扰表现为最低抑菌浓度增加和抑菌圈直径增大。用水提取法纯化琼脂可大幅降低这种不利影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297b/546838/69d9eda2a33e/applmicro00231-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297b/546838/69d9eda2a33e/applmicro00231-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297b/546838/69d9eda2a33e/applmicro00231-0048-a.jpg

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本文引用的文献

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The Influence of Certain Substances on the Activity of Streptomycin: III. Differential Effects of Various Electrolytes on the Action of Streptomycin.某些物质对链霉素活性的影响：III. 各种电解质对链霉素作用的差异效应
J Bacteriol. 1948 Jul;56(1):125-37.
2
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J Am Med Assoc. 1951 Dec 1;147(14):1336-41. doi: 10.1001/jama.1951.03670310026010.
3
Comparison of methods for determining sensitivity of bacteria to antibiotics in vitro.体外测定细菌对抗生素敏感性方法的比较。
米诺环素的体外抗菌活性及其药敏试验中所用琼脂培养基的影响。
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J Clin Microbiol. 1985 Mar;21(3):409-14. doi: 10.1128/jcm.21.3.409-414.1985.
5
Quality control of individual components used in Middlebrook 7H10 medium for mycobacterial susceptibility testing.用于分枝杆菌药敏试验的Middlebrook 7H10培养基中各成分的质量控制。
J Clin Microbiol. 1988 Nov;26(11):2338-42. doi: 10.1128/jcm.26.11.2338-2342.1988.
6
Selection of a reference lot of Mueller-Hinton agar.穆勒-欣顿琼脂参比批次的选择。
J Clin Microbiol. 1986 Jul;24(1):1-6. doi: 10.1128/jcm.24.1.1-6.1986.
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Antimicrob Agents Chemother. 1978 Mar;13(3):394-8. doi: 10.1128/AAC.13.3.394.
AMA Arch Intern Med. 1951 Oct;88(4):446-60. doi: 10.1001/archinte.1951.03810100030003.
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