Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

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作者信息

Pilch P F, Czech M P

出版信息

J Biol Chem. 1979 May 10;254(9):3375-81.

PMID:429356

Abstract

摘要

相似文献

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

J Biol Chem. 1979 May 10;254(9):3375-81.

Interactions between insulin and its receptors after the initial binding event. Functional heterogeneity and relationships to insulin degradation.初始结合事件后胰岛素与其受体之间的相互作用。功能异质性及其与胰岛素降解的关系。

Diabetes. 1979 May;28(5):460-71. doi: 10.2337/diab.28.5.460.

Modulation of hexose uptake and insulin action by cell membrane fluidity. The effects of temperature on membrane fluidity, insulin action, and insulin binding.细胞膜流动性对己糖摄取和胰岛素作用的调节。温度对膜流动性、胰岛素作用及胰岛素结合的影响。

J Biol Chem. 1979 Apr 25;254(8):2619-25.

Insulin can rapidly increase cell surface insulin binding capacity in rat adipocytes. A novel mechanism related to insulin sensitivity.胰岛素可迅速提高大鼠脂肪细胞的细胞表面胰岛素结合能力。这是一种与胰岛素敏感性相关的新机制。

Diabetes. 1992 Jun;41(6):707-14. doi: 10.2337/diab.41.6.707.

Effects of insulin on insulin-binding components extracted from rat fat cell membranes.胰岛素对从大鼠脂肪细胞膜提取的胰岛素结合成分的影响。

Nature. 1979 Mar 1;278(5699):61-2. doi: 10.1038/278061a0.

Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system.细胞松弛素B和D对大鼠脂肪细胞中胰岛素受体群体及胰岛素作用的影响。胰岛素受体与葡萄糖转运系统结构关系的可能证据。

J Clin Invest. 1979 Apr;63(4):571-9. doi: 10.1172/JCI109338.

The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.高亲和力胰岛素受体的亚基结构。脂肪细胞和肝细胞膜中存在二硫键连接的受体复合物的证据。

J Biol Chem. 1980 Feb 25;255(4):1722-31.

Evidence that the insulin-like activities of concanavalin A and insulin are mediated by a common insulin receptor linked effector system.伴刀豆球蛋白A和胰岛素的胰岛素样活性由一个共同的胰岛素受体连接效应系统介导的证据。

Biochemistry. 1981 Sep 29;20(20):5800-9. doi: 10.1021/bi00523a024.

Identification and characterization of a latent pool of insulin receptors in 3T3-L1 adipocytes.3T3-L1脂肪细胞中胰岛素受体潜伏池的鉴定与表征。

J Biol Chem. 1982 May 25;257(10):5350-8.

Inhibition by bacitracin of rat adipocyte plasma membrane degradation of 125I-insulin is associated with an increase in plasma membrane bound insulin and a potentiation of glucose oxidation by adipocytes.杆菌肽对大鼠脂肪细胞质膜降解¹²⁵I-胰岛素的抑制作用与质膜结合胰岛素的增加以及脂肪细胞葡萄糖氧化的增强有关。

J Biol Chem. 1982 Oct 10;257(19):11563-70.

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Nat Commun. 2022 Mar 18;13(1):1468. doi: 10.1038/s41467-022-28879-4.

The insulin-like growth factor II/mannose-6-phosphate receptor : IGF-II/Man-6-P receptor.胰岛素样生长因子 II/甘露糖-6-磷酸受体：IGF-II/Man-6-P 受体。

Cytotechnology. 1989 Dec;2(4):287-305. doi: 10.1007/BF00364994.

Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling.GLUT4 储存囊泡的蛋白质组学分析表明 LRP1 是囊泡的重要组成部分和胰岛素信号的靶标。

J Biol Chem. 2010 Jan 1;285(1):104-14. doi: 10.1074/jbc.M109.040428. Epub 2009 Oct 28.

Insulin-like growth factor II signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells.胰岛素样生长因子II通过胰岛素样生长因子II/甘露糖-6-磷酸受体发出信号，促进胰岛素分泌细胞的胞吐作用。

Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6232-7. doi: 10.1073/pnas.94.12.6232.

A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.胰岛素受体酪氨酸激酶结构域中的一个突变（Trp1193→Leu1193）与A型胰岛素抵抗综合征相关。

Diabetologia. 1993 May;36(5):414-22. doi: 10.1007/BF00402277.

Antibody penetration of viable human cells. II. Anti-RNP antibodies binding to RNP antigen expressed on cell surface, which may mediate the antibody internalization.抗体对活的人类细胞的穿透作用。II. 抗核糖核蛋白（RNP）抗体与细胞表面表达的RNP抗原结合，这可能介导抗体的内化。

Clin Exp Immunol. 1993 Sep;93(3):396-404. doi: 10.1111/j.1365-2249.1993.tb08191.x.

Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.一种模拟人胰岛素受体主要自身抗原表位的RNA分子的筛选。

Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2355-9. doi: 10.1073/pnas.92.6.2355.

Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes.胰岛素受体与胰岛素在肝细胞内被内化的生化和形态学证据。

J Cell Biol. 1982 Apr;93(1):82-7. doi: 10.1083/jcb.93.1.82.

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