初始结合事件后胰岛素与其受体之间的相互作用。功能异质性及其与胰岛素降解的关系。 - Suppr

Suppr

超能文献

Interactions between insulin and its receptors after the initial binding event. Functional heterogeneity and relationships to insulin degradation.

作者信息

Olefsky J M, Kobayashi M, Chang H

出版信息

Diabetes. 1979 May;28(5):460-71. doi: 10.2337/diab.28.5.460.

DOI:10.2337/diab.28.5.460

PMID:437375

Abstract

摘要

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Interactions between insulin and its receptors after the initial binding event. Functional heterogeneity and relationships to insulin degradation.初始结合事件后胰岛素与其受体之间的相互作用。功能异质性及其与胰岛素降解的关系。

Diabetes. 1979 May;28(5):460-71. doi: 10.2337/diab.28.5.460.

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.溶酶体促渗剂对胰岛素与脂肪细胞相互作用的影响。胰岛素加工和降解的溶酶体途径的证据。

J Biol Chem. 1979 Oct 25;254(20):10153-60.

Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes.

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Characterization of insulin-induced receptor loss and evidence for internalization of the insulin receptor.胰岛素诱导的受体丢失的特征及胰岛素受体内化的证据。

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Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

J Biol Chem. 1979 May 10;254(9):3375-81.

Receptor mediated insulin degradation decreased by chloroquine in isolated rat adipocytes.在分离的大鼠脂肪细胞中，氯喹降低了受体介导的胰岛素降解。

J Biochem. 1980 Jul;88(1):39-44.

Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system.细胞松弛素B和D对大鼠脂肪细胞中胰岛素受体群体及胰岛素作用的影响。胰岛素受体与葡萄糖转运系统结构关系的可能证据。

J Clin Invest. 1979 Apr;63(4):571-9. doi: 10.1172/JCI109338.

Evidence for recycling of insulin receptors in isolated rat adipocytes.大鼠分离脂肪细胞中胰岛素受体再循环的证据。

J Biol Chem. 1981 Nov 25;256(22):11464-70.

Internalization and intracellular processing of insulin and insulin receptors in adipocytes.脂肪细胞中胰岛素及胰岛素受体的内化与细胞内加工过程

Metabolism. 1982 Jul;31(7):670-90. doi: 10.1016/0026-0495(82)90197-4.

Internalized insulin-receptor complexes are unidirectionally translocated to chloroquine-sensitive degradative sites. Dependence on metabolic energy.内化的胰岛素受体复合物单向转运至对氯喹敏感的降解位点。对代谢能量的依赖性。

J Biol Chem. 1988 Apr 25;263(12):5961-9.

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Affinity change of the adipocyte receptor fails to alter insulin-stimulated glucose transport.脂肪细胞受体的亲和力变化未能改变胰岛素刺激的葡萄糖转运。

Biochem J. 1982 Jan 15;202(1):263-5. doi: 10.1042/bj2020263.

Insulin binding to liver plasma membranes from rats rendered diabetic by alloxan. A kinetic demonstration of two classes of binding sites in equilibrium with each other.胰岛素与经四氧嘧啶诱导成糖尿病的大鼠肝脏质膜的结合。两类相互处于平衡状态的结合位点的动力学证明。

Biochem J. 1982 Jan 15;202(1):259-62. doi: 10.1042/bj2020259.

Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes.胰岛素诱导大鼠脂肪细胞中胰岛素受体内化和降解的证据。

Proc Natl Acad Sci U S A. 1982 Jan;79(2):427-31. doi: 10.1073/pnas.79.2.427.

Insulin receptor binding and receptor-mediated insulin degradation in human adipocytes.人脂肪细胞中的胰岛素受体结合及受体介导的胰岛素降解

Diabetologia. 1981 Jun;20(6):636-41.

Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level.胰岛素孵育对分离的大鼠脂肪细胞胰岛素结合、葡萄糖转运及胰岛素降解的影响。激素诱导受体及受体后水平脱敏的证据。

J Clin Invest. 1980 Oct;66(4):763-72. doi: 10.1172/JCI109914.

Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries.具有独特亚基化学计量比的三种主要胰岛素受体结构的电泳分离。

Proc Natl Acad Sci U S A. 1980 Dec;77(12):7137-41. doi: 10.1073/pnas.77.12.7137.

Receptor- and non-receptor-mediated uptake and degradation of insulin by hepatocytes.肝细胞对胰岛素的受体介导和非受体介导摄取及降解

Biochem J. 1982 Oct 15;208(1):211-9. doi: 10.1042/bj2080211.

Ultrastructural basis for chloroquine-induced increase in intracellular insulin in adipocytes: alteration of lysosomal function.氯喹诱导脂肪细胞内胰岛素增加的超微结构基础：溶酶体功能的改变。

Proc Natl Acad Sci U S A. 1982 Dec;79(23):7302-6. doi: 10.1073/pnas.79.23.7302.

The fate of insulin in cardiac muscle. Studies on isolated muscle cells from adult rat heart.胰岛素在心肌中的命运。对成年大鼠心脏分离的肌肉细胞的研究。

Biochem J. 1982 Sep 15;206(3):655-62. doi: 10.1042/bj2060655.

Receptor-linked degradation of 125I-insulin is mediated by internalization in isolated rat hepatocytes.在分离的大鼠肝细胞中，125I胰岛素的受体连接降解是由内化作用介导的。

Yale J Biol Med. 1982 Mar-Apr;55(2):101-12.

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