携带缺陷型SV40基因组的人腺病毒（PARA）致癌潜力的变异
Variation in the oncogenic potential of human adenoviruses carrying a defective SV40 genome (PARA).
作者信息
Rapp F, Jerkofsky M, Melnick J L, Levy B
出版信息
J Exp Med. 1968 Jan 1;127(1):77-90. doi: 10.1084/jem.127.1.77.
The acquisition of the defective SV40 genome by a variety of human adenovirus serotypes by the process of transcapsidation has resulted in the addition of oncogenic potential for newborn hamsters to the previously nononcogenic adenovirus types 1, 2, 5, and 6. These serotypes have previously been grouped together by the high GC content of their DNA. Transcapsidation of the SV40 genome to weakly oncogenic adenovirus types 3, 14, 16, and 21 has failed to increase their oncogenic potential although the parent adenovirus type 7 carrying PARA is highly oncogenic. These serotypes belong to the group possessing a DNA of intermediate GC content. All the PARA-adenovirus populations, even those that were nononcogenic, were able to induce SV40 transplantation immunity and therefore carry the SV40 transplantation marker as well as the marker for synthesis of SV40 tumor or T antigen.
通过转衣壳过程，多种人类腺病毒血清型获得了有缺陷的SV40基因组，这使得之前无致癌潜力的1型、2型、5型和6型腺病毒对新生仓鼠有了致癌潜力。这些血清型此前因其DNA的高GC含量而被归为一组。虽然携带PARA的亲本7型腺病毒具有高度致癌性，但将SV40基因组转衣壳到致癌性较弱的3型、14型、16型和21型腺病毒中未能增加它们的致癌潜力。这些血清型属于具有中等GC含量DNA的组。所有携带PARA的腺病毒群体，即使是那些无致癌性的群体，都能够诱导SV40移植免疫，因此携带SV40移植标记以及SV40肿瘤或T抗原合成标记。
Zotero 插件