Pack B A, Tovar R, Booth E, Brooks S C
J Clin Endocrinol Metab. 1979 Mar;48(3):420-4. doi: 10.1210/jcem-48-3-420.
Human endometrial curettings were selected principally from patients undergoing tubal ligations for elective sterilization. Specimens were analyzed for the metabolism of 17beta-[6,7-3H]estradiol and Na2 35SO4; assayed for the nuclear receptor content with 17beta-[6,7-3H]estradiol; and examined for the cytosol receptor content with 17beta-[2,4,6,7-3H]estradiol. The results of these experiments demonstrated that a) estrogen sulfotransferase activity is greatly stimulated during the secretory phase; b) although estrogen dehydrogenase is active throughout the menstrual cycle, the formation of estrone is elevated in concert with sulfurylation; and c) this increased metabolism of 17beta-estradiol is accompanied by a decreased nuclear uptake of the estrogen receptor complex. The importance of this endometrial estrogen metabolism in the maintenance of a secretory tissue is discussed.
人子宫内膜刮除物主要取自因选择性绝育而接受输卵管结扎的患者。对标本进行17β-[6,7-³H]雌二醇和Na₂³⁵SO₄代谢分析；用17β-[6,7-³H]雌二醇测定核受体含量；用17β-[2,4,6,7-³H]雌二醇检测胞质溶胶受体含量。这些实验结果表明：a）雌激素磺基转移酶活性在分泌期受到极大刺激；b）尽管雌激素脱氢酶在整个月经周期都有活性，但雌酮的形成随着硫酸化作用而升高；c）17β-雌二醇这种增加的代谢伴随着雌激素受体复合物核摄取的减少。本文讨论了这种子宫内膜雌激素代谢在维持分泌组织中的重要性。
