酶消化后犬心肌小样本中利多卡因的气液色谱测定。
Gas-liquid chromatographic measurement of lignocaine in small samples of canine myocardium after enzymatic digestion.
作者信息
Holt D W, Loizou M, Wyse R K
出版信息
J Clin Pathol. 1979 Mar;32(3):225-8. doi: 10.1136/jcp.32.3.225.
Abstract
A method is described whereby lignocaine can be measured in small samples of canine myocardium. A proteolytic enzyme is used to digest the tissue, and the drug, together with an internal standard, is subsequently extracted into an organic solvent and measured by gas-liquid chromatography. The method is reproducible using tissue samples as small as 50 mg and appears to be suitable for the measurement of a number of drugs in small samples of tissue.
摘要
本文描述了一种可在犬心肌小样本中测量利多卡因的方法。使用一种蛋白水解酶消化组织，随后将药物与内标物一起萃取到有机溶剂中，并通过气液色谱法进行测量。该方法使用低至50毫克的组织样本即可重现，似乎适用于测量小组织样本中的多种药物。
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引用本文的文献
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High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in small tissue samples after enzymatic digestion.酶消化后小组织样本中胺碘酮和去乙基胺碘酮的高效液相色谱测定
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本文引用的文献
1
THE ESTIMATION OF LIDOCAINE AND PRILOCAINE IN BIOLOGICAL MATERIAL BY GAS CHROMATOGRAPHY.气相色谱法测定生物材料中的利多卡因和丙胺卡因
Scand J Clin Lab Invest. 1965;17:162-4.
2
Distribution of lidocaine in blood and tissue after single doses and steady infusion.单次给药及持续输注后利多卡因在血液和组织中的分布。
Res Commun Chem Pathol Pharmacol. 1971 Nov;2(6):813-28.
3
Determination of lidocaine in blood and tissues.血液和组织中利多卡因的测定。
Anesthesiology. 1973 Dec;39(6):639-41. doi: 10.1097/00000542-197312000-00017.
4
A simple method for gas chromatographic determination of lidocaine in tissues.一种用于气相色谱法测定组织中利多卡因的简单方法。
Anesthesiology. 1977 Nov;47(5):466-7. doi: 10.1097/00000542-197711000-00016.
5
Rapid micro-method for the measurement of phenobarbitone, primidone and phenytoin in blood plasma or serum by gas-liquid chromatography.
J Chromatogr. 1978 Sep 21;157:311-20. doi: 10.1016/s0021-9673(00)92348-3.
6
The extraction and analysis of benzodiazepines in tissues by enzymic digestion and high-performance liquid chromatography.通过酶消化和高效液相色谱法对组织中苯二氮䓬类药物进行提取和分析。
J Pharm Pharmacol. 1977 Aug;29(8):460-2. doi: 10.1111/j.2042-7158.1977.tb11369.x.
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