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本文引用的文献

1
THE EFFECT OF CALCIUM ON ACETYLCHOLINE RELEASE FROM MOTOR NERVE TERMINALS.钙对运动神经末梢乙酰胆碱释放的影响。
Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:496-503. doi: 10.1098/rspb.1965.0017.
2
THE MEASUREMENT OF SYNAPTIC DELAY, AND THE TIME COURSE OF ACETYLCHOLINE RELEASE AT THE NEUROMUSCULAR JUNCTION.神经肌肉接头处突触延迟的测量以及乙酰胆碱释放的时间进程。
Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:483-95. doi: 10.1098/rspb.1965.0016.
3
The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction.神经肌肉接头处钙离子与镁离子之间拮抗作用的本质。
J Physiol. 1957 Oct 30;138(3):434-44. doi: 10.1113/jphysiol.1957.sp005860.
4
Statistical factors involved in neuromuscular facilitation and depression.神经肌肉易化与抑制中的统计学因素。
J Physiol. 1954 Jun 28;124(3):574-85. doi: 10.1113/jphysiol.1954.sp005130.
5
Two components of facilitation at the neuromuscular junction of the frog.青蛙神经肌肉接头处易化作用的两个组成部分。
J Physiol. 1967 Jul;191(1):19P-20P.
6
On the relationship between calcium concentration and the amplitude of the end-plate potential.关于钙浓度与终板电位幅度之间的关系。
J Physiol. 1967 Apr;189(2):90P-92P.
7
The effect of temperature on the synaptic delay at the neuromuscular junction.温度对神经肌肉接头处突触延迟的影响。
J Physiol. 1965 Dec;181(3):656-70. doi: 10.1113/jphysiol.1965.sp007790.
8
Tetrodotoxin and neuromuscular transmission.河豚毒素与神经肌肉传递
Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):8-22. doi: 10.1098/rspb.1967.0010.
9
The release of acetylcholine from nerve endings by graded electric pulses.通过分级电脉冲使乙酰胆碱从神经末梢释放。
Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):23-38. doi: 10.1098/rspb.1967.0011.
10
Modification of transmitter release by electrical interference with motor nerve endings.通过对运动神经末梢进行电干扰来改变递质释放
Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):1-7. doi: 10.1098/rspb.1967.0008.

钙在神经肌肉易化中的作用。

The role of calcium in neuromuscular facilitation.

作者信息

Katz B, Miledi R

出版信息

J Physiol. 1968 Mar;195(2):481-92. doi: 10.1113/jphysiol.1968.sp008469.

DOI:10.1113/jphysiol.1968.sp008469
PMID:4296699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1351674/
Abstract
  1. The hypothesis is put forward that a residue of the ;active calcium' which enters the terminal axon membrane during the nerve impulse is responsible for short-term facilitation.2. This suggestion has been tested on the myoneural junction by varying the local calcium concentration so that during the first of two nerve impulses Ca is either much lower than, or raised to a level approaching that, during the second impulse. Facilitation is much larger in the latter case, which is in accordance with the ;calcium hypothesis'.3. A short pulse of depolarization focally applied to the junction is followed by a brief period of very intense facilitation. This can be seen in the tetrodotoxin-treated preparation, e.g. by lengthening the depolarization from 1 to 2 msec which can cause a more than fifty-fold increase in transmitter release. This large ;early facilitation' (which presumably occurs also during the course of a normal action potential) is discussed in relation to the ;calcium hypothesis'.
摘要

  1. 提出了这样一种假说：在神经冲动期间进入终末轴突膜的“活性钙”残余物是短期易化的原因。

  2. 此假说已在肌神经接头处进行了验证，通过改变局部钙浓度，使得在两个神经冲动中的第一个期间，Ca要么远低于第二个冲动期间的水平，要么升高到接近第二个冲动期间的水平。在后一种情况下，易化作用要大得多，这与“钙假说”相符。

  3. 局部施加于接头的短去极化脉冲之后会有一段非常强烈的易化的短暂时期。这在经河豚毒素处理的标本中可以看到，例如将去极化时间从1毫秒延长至2毫秒，这可使递质释放增加五十倍以上。这种大的“早期易化”（大概在正常动作电位过程中也会发生）结合“钙假说”进行了讨论。