碘缺乏大鼠甲状腺对促甲状腺素致甲状腺肿作用的敏感性增加。
Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin.
作者信息
Bray G A
出版信息
J Clin Invest. 1968 Jul;47(7):1640-7. doi: 10.1172/JCI105855.
Abstract
The present studies demonstrate that iodine depletion increases the sensitivity of the thyroid to the goitrogenic effects of thyrotropin. Iodine depletion was induced by feeding rats a low iodine diet containing propylthiouracil for 10-14 days before hypophysectomy. Accumulation of iodine in the thyroid after hypophysectomy was prevented by continuing the antithyroid drugs in the diet. Doses of thyrotropin as low as 3 mU/100 g of body weight per day produced significant thyroid enlargement in 3-7 days in iodine-depleted rats. Adding propylthiouracil or perchlorate to the diet during treatment with thyrotropin did not reduce or augment the goitrogenic response to thyrotropin in iodine-depleted rats. Increasing the level of circulating iodide also did not reduce the goitrogenic response to thyrotropin. The increased sensitivity of the iodine-depleted thyroid gland may provide an explanation for the development of thyroid enlargement without requiring an increased level of circulating thyrotropin.
摘要
目前的研究表明，碘缺乏会增加甲状腺对促甲状腺激素致甲状腺肿作用的敏感性。在垂体切除术前10 - 14天，通过给大鼠喂食含丙硫氧嘧啶的低碘饮食来诱导碘缺乏。通过在饮食中持续添加抗甲状腺药物，可防止垂体切除术后甲状腺中的碘积累。在碘缺乏的大鼠中，每天低至3 mU/100 g体重的促甲状腺激素剂量在3 - 7天内可使甲状腺显著肿大。在用促甲状腺激素治疗期间，在饮食中添加丙硫氧嘧啶或高氯酸盐不会降低或增强碘缺乏大鼠对促甲状腺激素的致甲状腺肿反应。增加循环碘化物水平也不会降低对促甲状腺激素的致甲状腺肿反应。碘缺乏甲状腺的敏感性增加可能为甲状腺肿大的发生提供一种解释，而无需循环促甲状腺激素水平升高。
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