Kessler C M, Bell W R
J Lab Clin Med. 1979 May;93(5):758-67.
Fibrinogen synthesis in rabbits was evaluated following intravenous infusions of stage 3 degradation products of homologous fibrinogen or fibrin, prepared in vitro. Fibrinogen production was measured by determining the rate of appearance of 75SeM into circulating fibrinogen. Fibrinogen synthesis increased threefold after the administration of stage 3 FDP (D and E), dialyzed to remove LMW digestion fragments, In contrast, the fdp obtained by plasminolysis of crosslinked thrombin clots or of noncrosslinked ancrod or thrombin clots failed to enhance basal fibrinogen production. Accelerated fibrinogen production was not accompanied by alterations in haptoglobin concentration or by increased incorporation of 75SeM into haptoglobin. Fibrinogen synthesis was not increased after infusions of FPA and FPB.
通过静脉输注体外制备的同源纤维蛋白原或纤维蛋白的3期降解产物，评估家兔体内的纤维蛋白原合成。通过测定75SeM进入循环纤维蛋白原的出现率来测量纤维蛋白原的产生。在给予经透析以去除低分子量消化片段的3期纤维蛋白降解产物（D和E）后，纤维蛋白原合成增加了三倍。相比之下，通过交联凝血酶凝块或非交联安克洛酶或凝血酶凝块的纤溶酶解获得的纤维蛋白降解产物未能提高基础纤维蛋白原的产生。纤维蛋白原产生加速并未伴随着触珠蛋白浓度的改变，也未伴随着75SeM掺入触珠蛋白的增加。输注纤维蛋白肽A和纤维蛋白肽B后，纤维蛋白原合成并未增加。
