Harmening D M, Dawson R B, Masters J M
Transfusion. 1979 Nov-Dec;19(6):675-81. doi: 10.1046/j.1537-2995.1979.19680104092.x.
A system using ion-exchange resins for the storage of whole blood was investigated. Blood was collected into CPD, thoroughly mixed and then divided into equal amounts. To one half of the split units, four grams of phosphate charged Amberlite IR-45 resin were added, while no additions were made to the other split units. Both aliquots were stored at 4 C, adhering to routine blood banking standards. The blood stored with the resin for up to 28 days maintained high levels of 2,3-DPG and adequate levels of ATP. This new resin system has several advantages over the present blood preservation technology. There is initial increase in pH that promotes greater glucose utilization. Inorganic phosphate is provided to maintain both ATP and 2,3-DPG levels. The resin buffers the blood and maintains a narrower pH range for red blood cell enzyme activity. The resin is totally inert, completely filterable and has the ability to adsorb bacteria from the suspending solution.
对一种使用离子交换树脂储存全血的系统进行了研究。血液被采集到CPD中，充分混合后分成等量的两份。在其中一份分开的血液中加入4克磷酸化的Amberlite IR - 45树脂，而另一份则不添加任何物质。两份等分样本均按照常规血库标准在4℃下储存。用树脂储存长达28天的血液维持了较高水平的2,3 - DPG和足够水平的ATP。这种新的树脂系统相对于目前的血液保存技术有几个优点。pH值最初会升高，这促进了更多的葡萄糖利用。提供无机磷酸盐以维持ATP和2,3 - DPG水平。树脂对血液起缓冲作用，并为红细胞酶活性维持更窄的pH范围。该树脂完全惰性，完全可过滤，并且有能力从悬浮液中吸附细菌。
