el-Shaboury A H
Br Med J. 1968 Sep 14;3(5619):653-5. doi: 10.1136/bmj.3.5619.653.
The synthetic polypeptide depot-tetracosactrin (Synacthen-Depot) was given to nine steroid-treated asthmatic patients hypersensitive to animal corticotrophin. Eight had a satisfactory increase in plasma and urinary 17-hydroxycorticosteroids (17-OHCS). The remaining patient had been shown previously to have adrenal suppression. None of the patients developed allergic reactions to depot-tetracosactrin, and seven have been receiving regular injections of the polypeptide twice weekly for the past eight months.In 13 normal subjects intramuscular injections of 1 mg. and 0.5 mg. of depot-tetracosactrin and 40 units of corticotrophin-gel were equally potent in raising the plasma 17-OHCS, but depot-tetracosactrin had a significantly longer action than corticotrophin-gel.
给9名对动物促肾上腺皮质激素过敏的接受过类固醇治疗的哮喘患者注射了合成多肽长效四促皮质素（长效促皮质素）。其中8名患者血浆和尿中17-羟皮质类固醇（17-OHCS）有令人满意的增加。其余1名患者先前已显示有肾上腺抑制。所有患者均未对长效四促皮质素发生过敏反应，并且在过去8个月中，有7名患者一直每周接受两次该多肽的定期注射。在13名正常受试者中，肌肉注射1毫克和0.5毫克长效四促皮质素以及40单位促皮质素凝胶，在提高血浆17-OHCS方面作用相同，但长效四促皮质素的作用明显比促皮质素凝胶持久。
