二十四肽促皮质素长期治疗对大鼠下丘脑-垂体-肾上腺功能的影响。
Effect of prolonged treatment with tetracosactrin on hypothalamo-pituitary-adrenal function in the rat.
作者信息
Hodges J R, Mitchley S
出版信息
Br J Pharmacol. 1971 Dec;43(4):804-13. doi: 10.1111/j.1476-5381.1971.tb07216.x.
Abstract
- The functional integrity of the hypothalamo-pituitary adrenal (HPA) system was assessed in rats after prolonged treatment with tetracosactrin.2. Adrenal size and sensitivity to corticotrophin were increased.3. Both the circadian rhythm and the stress-induced increase in HPA activity were inhibited. The circadian rhythm recovered before the response to stress.4. Tetracosactrin given after betamethasone treatment delayed the return of a normal HPA response to stress.5. Suppression of HPA activity appeared to be the result of a direct action of tetracosactrin and not entirely due to the elevations in the plasma corticosterone concentration which it caused.
摘要
在用二十四肽促皮质素进行长期治疗后，评估了大鼠下丘脑 - 垂体 - 肾上腺（HPA）系统的功能完整性。
肾上腺大小及对促肾上腺皮质激素的敏感性增加。
HPA活动的昼夜节律以及应激诱导的增加均受到抑制。昼夜节律在对应激的反应之前恢复。
在倍他米松治疗后给予二十四肽促皮质素延迟了HPA对应激的正常反应的恢复。
HPA活动的抑制似乎是二十四肽促皮质素直接作用的结果，而不完全归因于其引起的血浆皮质酮浓度的升高。
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