亚硝基甲基脲（MNU）：一种对小鼠皮肤有强大致癌性的物质。一项利用四氮唑试验（TZT）和皮肤局部应用的研究。
Nitrosomethylurea (MNU): a powerful carcinogen for mouse skin. A study utilising the tetrazolium test (TZT) and topical skin applications.
作者信息
Iversen O H
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 Jun 29;30(3):363-5. doi: 10.1007/BF02889114.
PMID:43013
Abstract
Nitrosomethylurea (MNU) was tested with the tetrazolium test for skin carcinogens with positive results. 39 hairless mice were painted once a week with a 1% solution of MNU in acetone. After 18 weeks all the animals bore tumours and 90% had skin carcinomas. Hence, the strong carcinogenic potency of MNU was confirmed, and the validity of the tetrazolium test was given further support.
摘要
用四氮唑试验对亚硝基甲基脲（MNU）进行皮肤致癌物检测，结果呈阳性。39只无毛小鼠每周用1%的MNU丙酮溶液涂抹一次。18周后，所有动物都长出了肿瘤，90%患有皮肤癌。因此，MNU的强致癌性得到了证实，四氮唑试验的有效性也得到了进一步支持。
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