Nitrosomethylurea (MNU): a powerful carcinogen for mouse skin. A study utilising the tetrazolium test (TZT) and topical skin applications.
作者信息
Iversen O H
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 Jun 29;30(3):363-5. doi: 10.1007/BF02889114.
PMID:43013
Abstract
Nitrosomethylurea (MNU) was tested with the tetrazolium test for skin carcinogens with positive results. 39 hairless mice were painted once a week with a 1% solution of MNU in acetone. After 18 weeks all the animals bore tumours and 90% had skin carcinomas. Hence, the strong carcinogenic potency of MNU was confirmed, and the validity of the tetrazolium test was given further support.
摘要
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Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 Jun 29;30(3):363-5. doi: 10.1007/BF02889114.
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