Ingham H R, Selkon J B, Codd A A, Hale J H
J Clin Pathol. 1968 Jul;21(4):432-6. doi: 10.1136/jcp.21.4.432.
During a two-year period of observation Bacteroides species were isolated from specimens of pus and vaginal swabs from 115 patients in this hospital. Thirty-five representative strains proved on examination to be Bacteroides fragilis. Minimal inhibitory and minimal bactericidal concentrations of six antibiotics for these strains were determined. All strains were resistant to streptomycin, neomycin, and polymyxin, slightly sensitive to penicillin and ampicillin, and fully sensitive to tetracycline, chloramphenicol, erythromycin, and lincomycin. The minimum bactericidal concentrations of chloramphenicol, erythromycin, and lincomycin were two to four times the minimal inhibitory concentrations. Tetracycline failed to exert any consistent bactericidal effect.The treatment of patients with infections caused by B. fragilis is discussed in the light of the findings in vitro.
在为期两年的观察期内，从本院115例患者的脓液标本和阴道拭子中分离出拟杆菌属菌种。经检查，35株代表性菌株为脆弱拟杆菌。测定了六种抗生素对这些菌株的最低抑菌浓度和最低杀菌浓度。所有菌株对链霉素、新霉素和多粘菌素耐药，对青霉素和氨苄西林轻度敏感，对四环素、氯霉素、红霉素和林可霉素完全敏感。氯霉素、红霉素和林可霉素的最低杀菌浓度是最低抑菌浓度的两到四倍。四环素未能发挥任何持续的杀菌作用。根据体外研究结果，对脆弱拟杆菌感染患者的治疗进行了讨论。
