甲硝唑对脆弱拟杆菌的杀菌活性。
Bactericidal activity of metronidazole against Bacteroides fragilis.
作者信息
Whelan J P, Hale J H
出版信息
J Clin Pathol. 1973 Jun;26(6):393-5. doi: 10.1136/jcp.26.6.393.
Abstract
Metronidazole was found to be active against Bacteroides fragilis strains isolated from human lesions. The minimal inhibitory concentrations (MIC) were from 0.16 to 2.5 mug/ml and the minimal bactericidal concentrations (MBC) were from 0.16 to 2.5 mug/ml; usually the MIC and MBC figures were equivalent. These levels are easily attainable in the serum following normal therapeutic doses. The drug is not toxic and side effects are rare and it would therefore seem highly suitable for treating Bacteroides infections and also may be considered prophylactically in certain situations that are described.
摘要
已发现甲硝唑对从人体病变中分离出的脆弱拟杆菌菌株具有活性。最低抑菌浓度（MIC）为0.16至2.5微克/毫升，最低杀菌浓度（MBC）为0.16至2.5微克/毫升；通常MIC和MBC数值相当。在正常治疗剂量后，血清中很容易达到这些水平。该药物无毒，副作用罕见，因此似乎非常适合治疗拟杆菌感染，在所述的某些情况下也可考虑用于预防。
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