饮食和葡萄糖诱导大鼠十二指肠和胰腺中血清素及血浆葡萄糖水平的变化。

Diet and glucose induced changes in rat duodenal and pancreatic serotonin and plasma glucose levels.

作者信息

Brown J E

出版信息

J Nutr. 1979 Feb;109(2):300-3. doi: 10.1093/jn/109.2.300.

DOI:10.1093/jn/109.2.300

Abstract

Serotonin concentrations in the duodenum and pancreas of rats fed 9, 22 (control), and 45% protein diets for 21 days were analyzed 15 minutes before (fasting levels) and 45 minutes after an oral glucose load. Fasting levels of serotonin were significantly higher in the duodenum of rats consuming the low and high protein diets. Plasma glucose levels were significantly higher in fasted rats receiving the low protein diet. Glucose load caused a significant decrease in duodenal concentration of serotonin and an increase in pancreatic serotonin among rats fed all three diets. The results suggest that duodenal serotonin levels change in response to diet composition whereas pancreatic serotonin is altered by glucose load.

摘要

对喂食9%、22%（对照）和45%蛋白质饮食21天的大鼠，在口服葡萄糖负荷前15分钟（空腹水平）和负荷后45分钟分析其十二指肠和胰腺中的血清素浓度。食用低蛋白和高蛋白饮食的大鼠十二指肠中血清素的空腹水平显著更高。接受低蛋白饮食的禁食大鼠血浆葡萄糖水平显著更高。在喂食所有三种饮食的大鼠中，葡萄糖负荷导致十二指肠中血清素浓度显著降低，胰腺血清素增加。结果表明，十二指肠血清素水平随饮食组成而变化，而胰腺血清素则受葡萄糖负荷影响而改变。