喂食不同水平硒、硫和α-生育酚的大鼠肠道和肝脏组织中的谷胱甘肽过氧化物酶活性

Glutathione peroxidase acitvity in intestinal and liver tissues of rats fed various levels of selenium, sulfur and alpha-tocopherol.

作者信息

Lane H W, Shirley R L, Cerda J J

出版信息

J Nutr. 1979 Mar;109(3):444-52. doi: 10.1093/jn/109.3.444.

DOI:10.1093/jn/109.3.444

Abstract

The effects of various levels of selenium, alpha-tocopherol and sulfur on glutathione peroxidase (GSH-Px) activity in intestinal and liver tissues were determined in male rats fed corn-soybean or Torula yeast diets. Rats fed corn-soybean diets had greater GSH-Px activity in the small intestine, colon and liver tissues, catalase activity and selenium in the liver, and body weight gains than those fed Torula yeast diets. GSH-Px activity in the small intestine, colon, and liver tissues as well as concentration of selenium in the liver increased with increasing levels of selenium in Torula yeast diets but not with corn-soybean diets. Tocopherol supplementation had no significant effect on GSH-Px activity in rats fed Torula yeast or corn-soybean diets supplemented with selenium. Supplemental sulfur decreased GSH-Px activity in the small intestine tissues and increased activity in colon tissues.

摘要

在以玉米 - 大豆或产朊假丝酵母日粮喂养的雄性大鼠中，测定了不同水平的硒、α - 生育酚和硫对肠道和肝脏组织中谷胱甘肽过氧化物酶（GSH - Px）活性的影响。与喂食产朊假丝酵母日粮的大鼠相比，喂食玉米 - 大豆日粮的大鼠在小肠、结肠和肝脏组织中的GSH - Px活性更高，肝脏中的过氧化氢酶活性和硒含量更高，体重增加也更多。在产朊假丝酵母日粮中，随着硒水平的增加，小肠、结肠和肝脏组织中的GSH - Px活性以及肝脏中的硒浓度升高，但在玉米 - 大豆日粮中则不然。补充生育酚对喂食添加硒的产朊假丝酵母或玉米 - 大豆日粮的大鼠的GSH - Px活性没有显著影响。补充硫会降低小肠组织中的GSH - Px活性，并增加结肠组织中的活性。