Turnlund J, Margen S
J Nutr. 1979 Mar;109(3):467-72. doi: 10.1093/jn/109.3.467.
Male weanling rats were fed diets containing less than 1, 3, 6 oor 13 ppm zinc or stock rat diet for 3 weeks. Each dietary group was subdivided into a control group and a prednisolone-treated group (5 mg pred/kg body weight). Femur and liver zinc contents were determined by flame atomic absorption spectrophotometry. Prednisolone caused growth retardation at all levels of dietary zinc. A marked increase was seen in femur zinc content of prednisolone-treated rats fed zinc-deficient diets. No such increase was seen in rats fed diets adequate in zinc. No significant change was seen in liver zinc content of zinc-deficient rats due to prednisolone. By comparing femur zinc in rats fed zinc-deficient diets with femur zinc in weanling rats, it appears that prednisolone causes an increase in femur zinc in rats fed deficient diets by (a) preventing bone resorption, and (b) increasing femur uptake of dietary zinc. Because the effects of glucocorticoids in rats appear to differ from effects in man, similar studies in other species are recommended.
雄性断乳大鼠分别喂食含锌量低于1、3、6或13 ppm的饲料或大鼠常规饲料，为期3周。每个饮食组再细分为对照组和泼尼松龙治疗组（5毫克泼尼松龙/千克体重）。通过火焰原子吸收分光光度法测定股骨和肝脏的锌含量。在所有饮食锌水平下，泼尼松龙都会导致生长迟缓。在喂食缺锌饲料的泼尼松龙治疗大鼠中，股骨锌含量显著增加。在喂食锌充足饲料的大鼠中未观察到这种增加。泼尼松龙对缺锌大鼠肝脏锌含量无显著影响。通过比较喂食缺锌饲料大鼠的股骨锌含量和断乳大鼠的股骨锌含量，似乎泼尼松龙通过（a）防止骨吸收和（b）增加股骨对膳食锌的摄取，导致喂食缺锌饲料大鼠的股骨锌含量增加。由于糖皮质激素对大鼠的影响似乎与人不同，建议在其他物种中进行类似研究。
