Fang M M, Lei K Y, Kilgore L T
J Nutr. 1980 May;110(5):1032-6. doi: 10.1093/jn/110.5.1032.
The effects of graded levels of dietary zinc on the development and mineralization of teeth and bones and on the susceptibility of teeth to dental caries were studied in young growing rats. Thirty-six weanling male Sprague-Dawley rats were randomly assigned to four dietary treatments: 1) zinc-deficient, less than 1 ppm; 2) 12 ppm zinc; 3) 36 ppm zinc, and 4) 108 ppm zinc. For treatments 2, 3 and 4, rats were pair-fed the quantity of feed consumed by their individual counterparts fed the zinc-deficient diet. After 4 weeks of treatment, growth retardation along with other clinical zinc deficiency signs were observed in rats fed the zinc-deficient diet. The zinc levels in bones and teeth of zinc-deficient rats were lower than those for rats fed supplemental zinc. Increased dietary zinc resulted in greater levels of zinc in bones and teeth, but the levels of calcium decreased. Greater incidences of enamel lesions in mandibular molars were observed in rats fed the zinc-deficient diet than in rats pair-fed zinc-supplemented diets. Furthermore, the effect of zinc deficiency on dental caries of young rats was predominantly at the smooth surfaces of the molars. Dietary zinc may be an important trace mineral in the process of post-eruptive mineralization of the enamel and may reduce the susceptibility of teeth to caries.
在幼年生长大鼠中研究了不同膳食锌水平对牙齿和骨骼发育、矿化以及牙齿患龋齿易感性的影响。将36只断乳雄性斯普拉格-道利大鼠随机分为四种膳食处理组：1）锌缺乏组，锌含量低于1 ppm；2）锌含量为12 ppm组；3）锌含量为36 ppm组；4）锌含量为108 ppm组。对于处理组2、3和4，给大鼠成对喂食其对应缺锌饮食组个体所消耗的饲料量。处理4周后，在喂食缺锌饮食的大鼠中观察到生长迟缓以及其他临床锌缺乏症状。缺锌大鼠骨骼和牙齿中的锌水平低于补充锌的大鼠。膳食锌增加导致骨骼和牙齿中的锌水平升高，但钙水平降低。与成对喂食补充锌饮食的大鼠相比，喂食缺锌饮食的大鼠下颌磨牙釉质病变发生率更高。此外，锌缺乏对幼鼠龋齿的影响主要发生在磨牙的光滑表面。膳食锌可能是釉质萌出后矿化过程中的一种重要微量矿物质，并且可能降低牙齿患龋齿的易感性。
