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猴脊髓内皮细胞和单核细胞内质网内的脊髓灰质炎病毒晶体。

Poliovirus crystals within the endoplasmic reticulum of endothelial and mononuclear cells in the monkey spinal cord.

作者信息

Blinzinger K, Simon J, Magrath D, Boulger L

出版信息

Science. 1969 Mar 21;163(3873):1336-7. doi: 10.1126/science.163.3873.1336.

DOI:10.1126/science.163.3873.1336
PMID:4303816
Abstract

The lumbar motor columns of a cynomolgus monkey that had become tetraplegic after experimental infection with a highly virulent strain of type 3 poliovirus were examined by electron microscopy. Crystalline aggregates of poliovirus occurred within the endoplasmic reticulum of endothelial cells as well as of mononuclear inflammatory cells. This finding suggests that the endoplasmic reticulum might be much more involved in poliovirus multiplication than has been previously supposed.

摘要

用高毒力3型脊髓灰质炎病毒实验感染后出现四肢瘫痪的食蟹猴的腰髓运动柱，通过电子显微镜进行了检查。脊髓灰质炎病毒的结晶聚集体出现在内皮细胞以及单核炎性细胞的内质网内。这一发现表明内质网可能比以前认为的更多地参与脊髓灰质炎病毒的增殖。

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