The growth of varicella-zoster virus in tissue fragments.

V-Z virus has been propagated in embryonic human skin, lung and kidney grafted on the chorio-allantois of hens' eggs or maintained as organ cultures The histological changes produced resemble those in the intact human host and the virus produced is cell-free as it is in vesicle fluid. It is suggested that organ cultures may provide a useful model for investigating virus synthesis but the method has not been found practical for the large scale production of cell-free virus in the laboratory.