McGinity J W, Mehta C S
Pharmacol Biochem Behav. 1978 Nov;9(5):705-8. doi: 10.1016/0091-3057(78)90226-5.
A new drug delivery system to induce physical dependence to morphine in rats is described. The device consists of a silicone polymer containing a water soluble "carrier" material, sodium alginate, which swells on contact with moisture to release the drug. The silicone or silastic pellets formulated to contain morphine sulfate are very easily prepared and the advantages over existing methods to induce physical dependence to morphine are discussed. In addition, a comparison of the percent of drug released and withdrawal intensities in rats was made with a silastic-morphine sulfate pellet, silastic-morphine base pellet and a microcrystalline cellulose-morphine base pellet.
本文描述了一种用于诱导大鼠对吗啡产生身体依赖性的新型药物递送系统。该装置由含有水溶性“载体”材料海藻酸钠的硅酮聚合物组成，海藻酸钠在与水分接触时会膨胀以释放药物。制备含有硫酸吗啡的硅酮或硅橡胶微丸非常容易，并讨论了其相对于现有诱导大鼠对吗啡产生身体依赖性方法的优势。此外，还对硅橡胶 - 硫酸吗啡微丸、硅橡胶 - 吗啡碱微丸和微晶纤维素 - 吗啡碱微丸在大鼠体内的药物释放百分比和戒断强度进行了比较。
