髓质海绵肾与肾性漏钙性高钙尿症。与甲状旁腺腺瘤的发生有关联吗？

Medullary sponge kidney and renal-leak hypercalciuria. A link to the development of parathyroid adenoma?

作者信息

Dlabal P W, Jordan R M, Dorfman S G

出版信息

JAMA. 1979 Apr 6;241(14):1490-1.

Abstract

The pathogenesis of the association of medullary sponge kidney and hyperparathyroidism from parathyroid adenoma remains obscure. This unusual case of medullary sponge kidney and secondary hyperparathyroidism due to renal-leak hypercalciuria gives insight into a possible mechanism for the occurrence of medullary sponge kidney with parathyroid adenoma. Suppressible hyperparathyroidism due to renal calcium wasting could represent an intermediate stage in the development of unsuppressible parathyroid hormone secretion. Thus, parathyroid adenoma occurring with medullary sponge kidney may represent a consequence of disordered renal calcium excretion rather than a primary abnormality.

摘要

髓质海绵肾与甲状旁腺腺瘤所致甲状旁腺功能亢进之间关联的发病机制仍不清楚。这例因肾性漏钙性高钙尿症导致的髓质海绵肾和继发性甲状旁腺功能亢进的罕见病例，为髓质海绵肾合并甲状旁腺腺瘤的发生提供了一种可能的机制。因肾钙流失导致的可抑制性甲状旁腺功能亢进可能是不可抑制性甲状旁腺激素分泌发展过程中的一个中间阶段。因此，与髓质海绵肾同时出现的甲状旁腺腺瘤可能是肾钙排泄紊乱的结果，而非原发性异常。