Marinelli M R, Beach K W, Glass M J, Primozich J F, Strandness D E
JAMA. 1979 May 11;241(19):2031-4.
In a prospective clinical study involving 458 diabetic patients, the results of noninvasive testing procedures were compared with the findings obtained by clinical evaluation. The results of the study showed that nearly one third of the patients who gave no history of intermittent claudication were found to have arterial disease when tested. One fifth of the patients with what were considered normal physical examination results had abnormal results by noninvasive testing. When history and physical examination prove ineffective for obtaining a diagnosis of arterial disease, the use of noninvasive devices effectively rules out or confirms the presence of hemodynamically significant arterial obstruction. Not only can simple, noninvasive testing methods greatly increase the accuracy of clinical diagnosis for the presence of arterial disease, but the baseline data obtained can serve as objective indexes to follow the natural history of the disease.
在一项涉及458名糖尿病患者的前瞻性临床研究中，将非侵入性检测程序的结果与临床评估所得结果进行了比较。研究结果表明，近三分之一自述无间歇性跛行病史的患者在接受检测时被发现患有动脉疾病。五分之一体格检查结果被认为正常的患者经非侵入性检测结果异常。当病史和体格检查对诊断动脉疾病无效时，使用非侵入性设备可有效排除或确认血流动力学上有显著意义的动脉阻塞的存在。简单的非侵入性检测方法不仅能大大提高动脉疾病临床诊断的准确性，而且所获得的基线数据可作为跟踪疾病自然史的客观指标。
