龙虾肌肉纤维抑制性突触后膜的离子通透性。
Ionic permeability of the inhibitory postsynaptic membrane of lobster muscle fibers.
作者信息
Motokizawa F, Reuben J P, Grundfest H
出版信息
J Gen Physiol. 1969 Oct;54(4):437-61. doi: 10.1085/jgp.54.4.437.
Abstract
Reversal potentials (E(IPSP)) of the inhibitory postsynaptic potential and the membrane resting potentials (E(M)) of lobster muscle fibers were determined with intracellular recording under a variety of ionic conditions. E(IPSP) is solely dependent on the electromotive force of anionic batteries; i.e., on the electrochemical gradient for a "mobile" fraction of intracellular Cl (Cl(i)) which is considerably smaller than the total intracellular Cl. The active inhibitory membrane is more permeable to certain "foreign" anions in the order NO(3) > SCN > Br > Cl. The membrane is impermeable to BrO(s), isethionate, and methylsulfate, but is slightly permeable to acetate and propionate. The level of Cl(i) appears to be determined in part by some active (pump?) process and most of the anions studied appear to interfere with the steady-state level of Cl(i).
摘要
在多种离子条件下，采用细胞内记录法测定了龙虾肌肉纤维抑制性突触后电位的反转电位（E(IPSP)）和膜静息电位（E(M)）。E(IPSP)仅取决于阴离子电池的电动势，即取决于细胞内Cl（Cl(i)）“可移动”部分的电化学梯度，该部分远小于细胞内总Cl。活性抑制膜对某些“外来”阴离子的通透性顺序为NO(3) > SCN > Br > Cl。该膜对BrO(s)、羟乙基磺酸酯和甲基硫酸盐不通透，但对乙酸盐和丙酸盐有轻微通透性。Cl(i)水平似乎部分由某种活性（泵？）过程决定，且所研究的大多数阴离子似乎会干扰Cl(i)的稳态水平。
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