家兔窦房结细胞中阴离子通道的特性
Characteristics of the anion channel in the sino-atrial node cell of the rabbit.
作者信息
Seyama I
出版信息
J Physiol. 1979 Sep;294:447-60. doi: 10.1113/jphysiol.1979.sp012940.
Abstract
- The anion permeability of the sino-atrial node cell membranes was determined by substituting various anions for Cl and observing the resultant transient changes in membrane potential. The permeability sequence was found to be in the following order: thiocyanate greater than NO3 greater than I Br greater than Cl greater than acetate. 2. The membrane resistance in Cl solution was compared with that in various anion solutions by the voltage-clamp method. The conductance sequence for the sino-atrial node cell membrane was observed to be the same as the permeability sequence. 3 The potential generated by the Na-K pump was partly short-circuited in normal bathing solution, and thus the pump could be responsible in part for the generation of the sin-atrial node resting membrane potential. 4 When Cl was replaced by acetate, a less permeable ion, the inward-going rectification disappeared. Thus, the inward-going rectification might be due partly to a time- and voltage-dependent Cl current.
摘要
- 通过用各种阴离子替代氯离子并观察由此产生的膜电位瞬态变化，测定了窦房结细胞膜的阴离子通透性。发现通透性顺序如下：硫氰酸盐大于硝酸根大于碘离子大于溴离子大于氯离子大于醋酸根。2. 用电压钳法比较了氯离子溶液中的膜电阻与各种阴离子溶液中的膜电阻。观察到窦房结细胞膜的电导顺序与通透性顺序相同。3. 在正常的浴液中，钠钾泵产生的电位部分被短路，因此该泵可能部分负责窦房结静息膜电位的产生。4. 当用通透性较低的离子醋酸根替代氯离子时，内向整流消失。因此，内向整流可能部分归因于时间和电压依赖性的氯离子电流。
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