三种抗生素对肾功能影响的对比研究
Comparative study of the effect of three antibiotics on renal function.
作者信息
Caldwell A D, Martin A J, Trigger D J
出版信息
Br J Pharmacol. 1969 Sep;37(1):283-93. doi: 10.1111/j.1476-5381.1969.tb09545.x.
Abstract
- Therapeutic doses of colistin sulphomethate sodium B.P. (Colomycin), pento-N sulphomethylpolymyxin B sodium (Thiosporin) and ampicillin B.P. (Penbritin) as well as normal saline have been given to volunteers with normal kidney function.2. A blind crossover technique was used and the effects of the compounds on blood levels and clearances of urea and creatinine studied.3. All four treatments resulted in some changes in the parameters measured but were reversible. The most marked changes were found with pento-N sulphomethylpolymyxin B sodium and were also associated with severe side-effects.4. In contrast to penicillins it is established that the process of tubular secretion sensitive to probenecid block plays no part in the renal excretion of polymyxins.
摘要
已将英国药典规定剂量的硫酸多粘菌素B钠（可洛迈仙）、戊-N-磺甲基多粘菌素B钠（硫孢霉素）、氨苄青霉素（青霉素V）以及生理盐水给予肾功能正常的志愿者。
采用了盲法交叉技术，并研究了这些化合物对尿素和肌酐血药浓度及清除率的影响。
所有四种治疗均导致所测参数出现一些变化，但这些变化是可逆的。戊-N-磺甲基多粘菌素B钠引起的变化最为显著，且还伴有严重的副作用。
与青霉素不同，已证实对丙磺舒阻滞敏感的肾小管分泌过程在多粘菌素的肾排泄中不起作用。
相似文献
1
Comparative study of the effect of three antibiotics on renal function.三种抗生素对肾功能影响的对比研究
Br J Pharmacol. 1969 Sep;37(1):283-93. doi: 10.1111/j.1476-5381.1969.tb09545.x.
2
Pharmacologic and toxicologic studies with the polymyxins. II. Comparative pharmnacologic studies of the sulfate and methanesulfonate salts of polymyxin B and colistin in dogs.多粘菌素的药理与毒理学研究。II. 多粘菌素B和粘菌素的硫酸盐及甲磺酸盐在犬体内的比较药理研究。
Chemotherapy. 1973;19(2):82-97. doi: 10.1159/000221443.
3
Polymyxin B, colistin, and sodium colistimethate.多黏菌素B、黏菌素和黏菌素甲磺酸钠。
Med Clin North Am. 1982 Jan;66(1):135-42. doi: 10.1016/s0025-7125(16)31447-x.
4
Effects of large doses of colistin sulphomethate sodium on renal function.大剂量硫酸多粘菌素B钠对肾功能的影响。
Br Med J. 1970 Nov 28;4(5734):525-7. doi: 10.1136/bmj.4.5734.525.
5
The activity of polymyxins against dense populations of Escherichia coli.多粘菌素对高密度大肠杆菌群体的活性。
J Gen Microbiol. 1975 Nov;91(1):110-8. doi: 10.1099/00221287-91-1-110.
6
Measurement of urinary N-acetyl-b-D-glucosaminidase in adult patients with cystic fibrosis: before, during and after treatment with intravenous antibiotics.成年囊性纤维化患者尿N-乙酰-β-D-氨基葡萄糖苷酶的测定：静脉使用抗生素治疗前、治疗期间及治疗后
J Cyst Fibros. 2007 Jan;6(1):67-73. doi: 10.1016/j.jcf.2006.05.013. Epub 2006 Jul 17.
7
Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B?多粘菌素的肾毒性：粘菌素甲磺酸钠与多粘菌素B之间有差异吗？
Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.02319-16. Print 2017 Mar.
8
Intravenous colistin sulphomethate in acute respiratory exacerbations in adult patients with cystic fibrosis.静脉注射硫酸多黏菌素甲磺酸钠治疗成年囊性纤维化患者急性呼吸道加重期
Thorax. 1997 Nov;52(11):987-93. doi: 10.1136/thx.52.11.987.
9
The activity of polymyxins against Escherichia coli in an in-vitro model of the urinary bladder.多粘菌素在膀胱体外模型中对大肠杆菌的活性。
J Med Microbiol. 1977 May;10(2):255-9. doi: 10.1099/00222615-10-2-255.
10
Potential Toxicity of Polymyxins in Human Lung Epithelial Cells.多粘菌素对人肺上皮细胞的潜在毒性
Antimicrob Agents Chemother. 2017 May 24;61(6). doi: 10.1128/AAC.02690-16. Print 2017 Jun.
引用本文的文献
1
Effects of large doses of colistin sulphomethate sodium on renal function.大剂量硫酸多粘菌素B钠对肾功能的影响。
Br Med J. 1970 Nov 28;4(5734):525-7. doi: 10.1136/bmj.4.5734.525.
本文引用的文献
1
A rapid method for the estimation of urea in biologic fluids.一种估算生物体液中尿素的快速方法。
Am J Clin Pathol. 1951 Mar;21(3):275-81. doi: 10.1093/ajcp/21.3_ts.275.
2
THE CHEMICAL STRUCTURE OF POLYMYXIN E: THE IDENTITIES OF POLYMYXIN E1 WITH COLISTIN A AND OF POLYMYXIN E2 WITH COLISTIN B.多粘菌素E的化学结构：多粘菌素E1与黏菌素A以及多粘菌素E2与黏菌素B的一致性
J Biochem. 1965 Feb;57:226-7. doi: 10.1093/oxfordjournals.jbchem.a128082.
3
SODIUM SULPHOMETHYL DERIVATIVES OF POLYMYXINS.多粘菌素的磺甲基钠衍生物
Br J Pharmacol Chemother. 1964 Dec;23(3):552-74. doi: 10.1111/j.1476-5381.1964.tb01610.x.
4
STRUCTURES OF POLYMYXIN B2 AND POLYMYXIN E1.多粘菌素B2和多粘菌素E1的结构
Nature. 1964 Dec 5;204:993-4. doi: 10.1038/204993a0.
5
THE EFFECT OF PROBENECID IN DELAYING THE URINARY EXCRETIONS OF THE NEW PENICILLINS DERIVED FROM 6-AMINOPENICILLANIC ACID.丙磺舒对延缓由6-氨基青霉烷酸衍生的新型青霉素尿液排泄的作用。
Br J Clin Pract. 1964 Oct;18:593-600.
6
INTRAVENOUS ADMINISTRATION OF SODIUM COLISTIMETHATE.多粘菌素E甲磺酸钠的静脉给药
JAMA. 1964 Oct 26;190:278-81. doi: 10.1001/jama.1964.03070170019004.
7
"COLOMYCIN" TREATMENT OF KLEBSIELLA AEROGENES INFECTION OF URINARY TRACT IN PARAPLEGIA.“黏菌素”治疗截瘫患者产气克雷伯菌所致的尿路感染
Br Med J. 1963 Sep 28;2(5360):790-2. doi: 10.1136/bmj.2.5360.790.
8
RENAL AND POSSIBLY HEPATIC TOXICITY FROM COLY-MYCIN. REPORT OF A CASE.
Med Ann Dist Columbia. 1963 Oct;32:408-13.
9
Absorption and excretion of "Penbritin".“青霉素V钾片”的吸收与排泄
Br Med J. 1961 Jul 22;2(5246):198-200. doi: 10.1136/bmj.2.5246.198.
10
The determination of creatinine in plasma or serum, and in urine; a critical examination.血浆、血清及尿液中肌酐的测定：一项批判性研究。
Biochem J. 1954 Nov;58(3):426-37. doi: 10.1042/bj0580426.
Zotero 插件