Kaiser H, Spaar U, Sold G, Wolfrum D I, Kreuzer H
Klin Wochenschr. 1979 Mar 1;57(5):225-35. doi: 10.1007/BF01477491.
A radioimmunoassay was developed to determine serum myoglobin (SMb). 50 healthy persons showed values between 0 and 90 ng/ml. Serial tests of 10 patients following acute myocardial infarction or during angina pectoris (AP) indicated that SMb reached pathological values before CK and CK-MB (average 250 +/- 95 ng/ml at the time of hospitalisation which corresponds to 3.3 +/- 1.4 h after beginning of angina pectoris). At hospitalisation the simultaneously determined CK was within normal limits and reached pathological values only 6.2 +/- 1.9 h after the onset of angina. Maximum of SMb was 506 +/- 194 ng/ml occurring 8.8 +/- 2.8 h after beginning of AP, maximum of CK was 905 +/- 475 mU/ml occurring 20.0 +/- 7.8 h after AP. CK-MB and CK differed only slightly in their time course. One patient with severe AP had pathologically increased SMb values whilst all other enzymes were completely normal. Methodical and clinical results are discussed.
已开发出一种放射免疫分析法来测定血清肌红蛋白（SMb）。50名健康人的SMb值在0至90纳克/毫升之间。对10例急性心肌梗死患者或心绞痛（AP）发作期间患者的系列检测表明，SMb在肌酸激酶（CK）和肌酸激酶同工酶（CK-MB）之前达到病理值（住院时平均为250±95纳克/毫升，相当于心绞痛发作开始后3.3±1.4小时）。住院时同时测定的CK在正常范围内，仅在心绞痛发作后6.2±1.9小时才达到病理值。AP开始后8.8±2.8小时，SMb的最大值为506±194纳克/毫升；AP开始后20.0±7.8小时，CK的最大值为905±475毫国际单位/毫升。CK-MB和CK在其时间进程上仅有轻微差异。1例重度AP患者的SMb值病理性升高，而所有其他酶均完全正常。对方法学和临床结果进行了讨论。
