Black P H, Berman L D, Dixon C B
J Virol. 1969 Nov;4(5):694-703. doi: 10.1128/JVI.4.5.694-703.1969.
Clones were isolated from hamster cells transformed by the adenovirus 2-SV40 and adenovirus 12-SV40 transcapsidant hybrid viruses. The clones were characterized with respect to their cytomorphology, virus and antigen content, and the histomorphology of tumors induced by transplantation of the clonal sublines to hamsters. Three different cellular and colonial morphologies were observed. Clones with an SV40 morphology gave rise to tumors predominantly with an SV40 histology, whereas clones with an adenovirus morphology produced typical adenovirus tumors upon transplantation of the transformed cells. Clones which had features of both SV40 and adenovirus transformed cells gave rise to "intermediate" and adenovirus tumors. The results indicate that multiple events occur during transformation and tumorigenesis by the transcapsidant virus populations and provide an explanation for the multiplicity of findings which have been reported with these virus populations.
从经腺病毒2 - SV40和腺病毒12 - SV40转壳杂交病毒转化的仓鼠细胞中分离出克隆。对这些克隆在细胞形态学、病毒和抗原含量以及将克隆亚系移植到仓鼠后诱导产生的肿瘤的组织形态学方面进行了表征。观察到三种不同的细胞和菌落形态。具有SV40形态的克隆主要产生具有SV40组织学特征的肿瘤，而具有腺病毒形态的克隆在移植转化细胞后产生典型的腺病毒肿瘤。具有SV40和腺病毒转化细胞特征的克隆产生“中间型”和腺病毒肿瘤。结果表明，转壳病毒群体在转化和肿瘤发生过程中发生了多个事件，并为这些病毒群体所报道的多种发现提供了解释。
