Jensen F, Defendi V
J Virol. 1968 Mar;2(3):173-7. doi: 10.1128/JVI.2.3.173-177.1968.
The ability of adenovirus 7-simian virus 40 (SV40) hybrid (strain LL "E-46") to replicate decreased exponentially as a function of the amount of gamma-irradiation; the ability to induce SV40 and adenovirus 7 T antigen decreased at a much slower rate. Nevertheless, the virus was still able to transform African green monkey kidney cells at a radiation dosage that had completely destroyed its replication ability. All transformed colonies were positive for SV40 T antigen but were negative for adenovirus 7 T antigen. The adenovirus 7-SV40 hybrid transformed cells were superinfectible with SV40 virus. Two of the three transformed cell populations apparently did not sensitize hamsters against the appearance SV40 primary tumors, thus suggesting a deficiency in the SV40 transplantation antigen.
腺病毒7-猴病毒40（SV40）杂交体（菌株LL“E-46”）的复制能力随γ辐射量呈指数下降；诱导SV40和腺病毒7 T抗原的能力下降速度则慢得多。然而，该病毒在辐射剂量完全破坏其复制能力的情况下，仍能够转化非洲绿猴肾细胞。所有转化菌落的SV40 T抗原呈阳性，但腺病毒7 T抗原呈阴性。腺病毒7-SV40杂交体转化细胞对SV40病毒具有超感染性。三个转化细胞群体中有两个显然未使仓鼠对SV40原发性肿瘤的出现产生致敏作用，因此表明SV40移植抗原有缺陷。
