2-巯基-1（β-4-吡啶乙基）苯并咪唑的作用机制：一种干扰素活性的可逆抑制剂。
Mechanism of action of 2-mercapto-1(beta-4-pyridethyl)benzimidazole: a reversible inhibitor of interferon activity.
作者信息
Friedman R M, Pastan I
出版信息
Proc Natl Acad Sci U S A. 1970 Jan;65(1):104-9. doi: 10.1073/pnas.65.1.104.
Abstract
2-mercapto-1(beta-4-pyridethyl)benzimidazole (MPB) inhibited the development of antiviral activity induced by interferon in chick cells. The MPB effect was reversed by washing the cells. The action of MPB was on a step immediately following interferon binding but before the cellular RNA and protein synthesis that appear to be required for interferon action. The step blocked by MPB possibly involves cellular phospholipid synthesis.
摘要
2-巯基-1（β-4-吡啶乙基）苯并咪唑（MPB）抑制了干扰素在鸡细胞中诱导的抗病毒活性的发展。通过洗涤细胞可逆转MPB的作用。MPB的作用发生在干扰素结合之后紧接着的一个步骤，但在干扰素作用所需的细胞RNA和蛋白质合成之前。被MPB阻断的这一步骤可能涉及细胞磷脂合成。
相似文献
1
Mechanism of action of 2-mercapto-1(beta-4-pyridethyl)benzimidazole: a reversible inhibitor of interferon activity.2-巯基-1（β-4-吡啶乙基）苯并咪唑的作用机制：一种干扰素活性的可逆抑制剂。
Proc Natl Acad Sci U S A. 1970 Jan;65(1):104-9. doi: 10.1073/pnas.65.1.104.
2
The effect of 2-mercapto-1-(beta-4-pyridethyl) benzimidazole (MPB) on cell differentiation and RNA synthesis in the protozoon Tetrahymena vorax.2-巯基-1-（β-4-吡啶乙基）苯并咪唑（MPB）对嗜食四膜虫细胞分化和RNA合成的影响。
J Protozool. 1971 Feb;18(1):87-90. doi: 10.1111/j.1550-7408.1971.tb03286.x.
3
The uptake of nucleosides by cells in culture. II. Inhibition by 2-mercapto-1-(beta-4-pyridethyl)benzimidazole.培养细胞对核苷的摄取。II. 2-巯基-1-（β-4-吡啶乙基）苯并咪唑的抑制作用
Biochim Biophys Acta. 1969 Oct 22;190(2):250-6. doi: 10.1016/0005-2787(69)90076-8.
4
2-mercapto-1-( -4-pyridethyl) benzimidazole, an inhibitor of RNA synthesis: a reevaluation.
Biochem Biophys Res Commun. 1971 Oct 1;45(1):265-9. doi: 10.1016/0006-291x(71)90079-9.
5
Actinomycin D: inhibition of phospholipid synthesis in chick embryo cells.放线菌素D：对鸡胚细胞中磷脂合成的抑制作用。
Science. 1968 Apr 19;160(3825):316-7. doi: 10.1126/science.160.3825.316.
6
Blocking of interferon action by a component of normal serum.正常血清中的一种成分对干扰素作用的阻断。
Arch Gesamte Virusforsch. 1970;31(1):18-27. doi: 10.1007/BF01241662.
7
Effects of actinomycin D and 2-mercapto-1-(beta-4-pyridethyl) benzimidazole on the incorporation of [3H]uridine by chick embryo cells.放线菌素D和2-巯基-1-（β-4-吡啶乙基）苯并咪唑对鸡胚细胞掺入[3H]尿苷的影响。
Biochim Biophys Acta. 1967 Jul 18;142(2):430-9. doi: 10.1016/0005-2787(67)90624-7.
8
Depression of interferon production in chick embryo cells by rifampicin.利福平对鸡胚细胞中干扰素产生的抑制作用。
J Gen Virol. 1972 May;15(2):139-48. doi: 10.1099/0022-1317-15-2-139.
9
A study of factors regulating RNA synthesis in HeLa cells using MPB, a reversible inhibitor of RNA synthesis.
Biochem Biophys Res Commun. 1968 Feb 26;30(4):350-5. doi: 10.1016/0006-291x(68)90749-3.
10
Effects of cyclic AMP and of 2-mercapto-1-(beta-4-pyridethyl)benzimidazole on composition of steroids secreted by a testicular tumour cell line.
J Steroid Biochem. 1979 Nov-Dec;11(5-6):1507-12. doi: 10.1016/0022-4731(79)90340-6.
引用本文的文献
1
Antiviral activity of interferons.干扰素的抗病毒活性。
Bacteriol Rev. 1977 Sep;41(3):543-67. doi: 10.1128/br.41.3.543-567.1977.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
MECHANISM OF ACTION OF COLICINES.大肠杆菌素的作用机制
Proc Natl Acad Sci U S A. 1964 Dec;52(6):1514-21. doi: 10.1073/pnas.52.6.1514.
3
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
4
Effects of actinomycin D and 2-mercapto-1-(beta-4-pyridethyl) benzimidazole on the incorporation of [3H]uridine by chick embryo cells.放线菌素D和2-巯基-1-（β-4-吡啶乙基）苯并咪唑对鸡胚细胞掺入[3H]尿苷的影响。
Biochim Biophys Acta. 1967 Jul 18;142(2):430-9. doi: 10.1016/0005-2787(67)90624-7.
5
A reversible inhibitor of nucleic acid synthesis.一种核酸合成的可逆抑制剂。
Nature. 1967 Mar 18;213(5081):1099-101. doi: 10.1038/2131099a0.
6
Further purification of chick interferon.
Nature. 1965 Sep 18;207(5003):1298. doi: 10.1038/2071298a0.
7
Interferon binding: the first step in establishment of antiviral activity.干扰素结合：建立抗病毒活性的第一步。
Science. 1967 Jun 30;156(3783):1760-1. doi: 10.1126/science.156.3783.1760.
8
Lipoamino acids as precursors in the synthesis of authentic proteins by homogenates of hen oviduct.脂氨基酸作为鸡输卵管匀浆合成天然蛋白质的前体。
Proc Natl Acad Sci U S A. 1965 Oct;54(4):1233-40. doi: 10.1073/pnas.54.4.1233.
9
The effects of substituted benzimidazoles on the growth of viruses and the nucleic acid metabolism of host cells.
J Gen Virol. 1967 Jan;1(1):89-99. doi: 10.1099/0022-1317-1-1-89.
10
Interferon production and RNA inhibitors.干扰素产生与RNA抑制剂。
J Gen Virol. 1967 Jul;1(3):349-62. doi: 10.1099/0022-1317-1-3-349.
Zotero 插件