2-巯基-1（β-4-吡啶乙基）苯并咪唑的作用机制：一种干扰素活性的可逆抑制剂。
Mechanism of action of 2-mercapto-1(beta-4-pyridethyl)benzimidazole: a reversible inhibitor of interferon activity.
作者信息
Friedman R M, Pastan I
出版信息
Proc Natl Acad Sci U S A. 1970 Jan;65(1):104-9. doi: 10.1073/pnas.65.1.104.
Abstract
2-mercapto-1(beta-4-pyridethyl)benzimidazole (MPB) inhibited the development of antiviral activity induced by interferon in chick cells. The MPB effect was reversed by washing the cells. The action of MPB was on a step immediately following interferon binding but before the cellular RNA and protein synthesis that appear to be required for interferon action. The step blocked by MPB possibly involves cellular phospholipid synthesis.
摘要
2-巯基-1（β-4-吡啶乙基）苯并咪唑（MPB）抑制了干扰素在鸡细胞中诱导的抗病毒活性的发展。通过洗涤细胞可逆转MPB的作用。MPB的作用发生在干扰素结合之后紧接着的一个步骤，但在干扰素作用所需的细胞RNA和蛋白质合成之前。被MPB阻断的这一步骤可能涉及细胞磷脂合成。
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