吡唑对慢性乙醇给药对大鼠肝脏烟酰胺 - 腺嘌呤二核苷酸（磷酸）偶联的氧化还原状态以及肝脏和大脑色氨酸代谢影响的预防作用
Prevention by pyrazole of the effects of chronic ethanol administration on the redox states of the hepatic nicotinamide--adenine dinucleotide (phosphate) couples and on liver and brain tryptophan metabolism in the rat.
作者信息
Punjani N F, Badawy A A, Evans M
出版信息
Biochem J. 1979 Oct 15;184(1):165-8. doi: 10.1042/bj1840165.
Abstract
Chronic administration of pyrazole in the diet of rats does not cause toxicity and prevents the chronic effects of ethanol on: (1) the redox states of the hepatic NAD(P) couples; (2) liver tryptophan pyrrolase activity; (3) brain tryptophan and 5-hydroxytryptamine metabolism.
摘要
在大鼠饮食中持续给予吡唑不会导致毒性，并且可预防乙醇对以下方面的慢性影响：(1)肝脏NAD(P)偶联物的氧化还原状态；(2)肝脏色氨酸吡咯酶活性；(3)脑色氨酸和5-羟色胺代谢。
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Prevention by pyrazole of the effects of chronic ethanol administration on the redox states of the hepatic nicotinamide--adenine dinucleotide (phosphate) couples and on liver and brain tryptophan metabolism in the rat.吡唑对慢性乙醇给药对大鼠肝脏烟酰胺 - 腺嘌呤二核苷酸（磷酸）偶联的氧化还原状态以及肝脏和大脑色氨酸代谢影响的预防作用
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本文引用的文献
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Effect of pyrazoles and other compounds on alcohol metabolism.吡唑类及其他化合物对酒精代谢的影响。
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Liver cell necrosis in rats after prolonged ethanol ingestion under the influence of an alcohol-dehydrogenase inhibitor.在乙醇脱氢酶抑制剂影响下长期摄入乙醇后大鼠的肝细胞坏死
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Effect of pyrazole on the induction of fatty liver by chronic administration of ethanol.吡唑对慢性给予乙醇诱导脂肪肝的影响。
Biochem Pharmacol. 1972 Mar 15;21(6):811-9. doi: 10.1016/0006-2952(72)90124-4.
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Effect of chronic intake of ethanol on pyridine nucleotide levels in rat liver and kidney.长期摄入乙醇对大鼠肝脏和肾脏中吡啶核苷酸水平的影响。
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Pyrazole and induction of fatty liver by a single dose of ethanol.吡唑与单剂量乙醇诱导的脂肪肝
Science. 1970 Jun 26;168(3939):1598-9. doi: 10.1126/science.168.3939.1598.
6
An assay procedure for nicotinamide-adenine dinucleotides in rat liver and other tissues.大鼠肝脏及其他组织中烟酰胺腺嘌呤二核苷酸的测定方法。
Arch Int Physiol Biochim. 1964 Jun;72(3):427-47. doi: 10.3109/13813456409065351.
7
The effects of ethanol on tryptophan pyrrolase activity and their comparison with those of phenobarbitone and morphine.乙醇对色氨酸吡咯酶活性的影响及其与苯巴比妥和吗啡影响的比较。
Adv Exp Med Biol. 1975;59:229-51. doi: 10.1007/978-1-4757-0632-1_15.
8
Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms.大鼠肝脏色氨酸吡咯酶受其辅因子血红素的调控：血红素和5-氨基乙酰丙酸的实验及与底物和激素机制的比较。
Biochem J. 1975 Sep;150(3):511-20. doi: 10.1042/bj1500511.
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Effects of pyrazole on rat liver tryptophan oxygenase.吡唑对大鼠肝脏色氨酸加氧酶的影响。
Life Sci. 1976 Aug 15;19(4):505-14. doi: 10.1016/0024-3205(76)90229-0.
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Liver tryptophan pyrrolase and brain 5-hydroxytryptamine: effects of chronic ethanol administration.肝脏色氨酸吡咯酶与脑5-羟色胺：长期乙醇给药的影响
Biochem Soc Trans. 1978;6(5):1002-4. doi: 10.1042/bst0061002.
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