Keating M J, Bodey G P, Valdivieso M, Rodriguez V
Medicine (Baltimore). 1979 Mar;58(2):159-70. doi: 10.1097/00005792-197903000-00004.
Continuous infusions of gentamicin, amikacin or sisomicin combined with carbenicillin were compared in a randomized study in the treatment of 572 febrile episodes in 281 patients with cancer. The three treatments (C+A, C+A and C+S) were equally effective with no significant differences in response rate overall (67%, 68%, 67%) or in any infection, except septicemia where C+G had a significantly lower response rate than the other two groups. Pneumonia, the most common infection, had the lowest response rate for all three groups (45-50%). Klebsiella spp. were the most common pathogens and showed a lower response rate than other gram-negative bacilli (P = 0.003). Patients with persistent severe neutropenia had a response rate of 56%. Azotemia was significantly less common in patients with documented infection treated with C+A than in the C+S group. Combinations of carbenicillin plus an aminoglycoside antibiotic are effective for the treatment of infections in neutropenic patients.
在一项随机研究中，对281例癌症患者的572次发热发作，比较了庆大霉素、阿米卡星或西索米星与羧苄西林联合持续输注的治疗效果。三种治疗方法（C+G、C+A和C+S）效果相同，总体有效率（67%、68%、67%）无显著差异，在任何感染中也无显著差异，但在败血症方面，C+G的有效率显著低于其他两组。肺炎是最常见的感染，三组的有效率最低（45%-50%）。克雷伯菌属是最常见的病原体，其有效率低于其他革兰氏阴性杆菌（P=0.003）。持续性严重中性粒细胞减少的患者有效率为56%。记录显示，接受C+A治疗的感染患者中氮质血症的发生率明显低于C+S组。羧苄西林加氨基糖苷类抗生素联合用药对治疗中性粒细胞减少患者的感染有效。
