Kato M
J Bacteriol. 1970 Mar;101(3):709-16. doi: 10.1128/jb.101.3.709-716.1970.
The toxicity for mice of the cord factor of Cornebacterium diphtheriae, trehalose-6,6'-dicorynomycolate, was studied. The diphtherial cord factor showed a delayed lethal toxicity for mice; the median lethal dose was 120 mug. Mouse liver mitochondria were disrupted in vivo under the toxic action of the diphtherial cord factor into fragments deficient in both respiration and phosphorylation. The site of metabolic defect in the mitochondrial electron transport system was located at the region prior to the level of cytochrome c in the livers of cord factor-intoxicated mice. These effects of the diphtherial cord factor on the host-cell mitochondria were essentially similar to those of the cord factor of Mycobacterium tuberculosis, trehalose-6,6'-dimycolate.
对白喉棒状杆菌的索状因子海藻糖 -6,6'- 二分枝菌酸对小鼠的毒性进行了研究。白喉索状因子对小鼠呈现出延迟性致死毒性；半数致死剂量为120微克。在白喉索状因子的毒性作用下，小鼠肝脏线粒体在体内被破坏成呼吸和磷酸化均有缺陷的片段。在索状因子中毒小鼠的肝脏中，线粒体电子传递系统的代谢缺陷位点位于细胞色素c水平之前的区域。白喉索状因子对宿主细胞线粒体的这些作用与结核分枝杆菌的索状因子海藻糖 -6,6'- 二霉菌酸的作用基本相似。
