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Action of a toxic glycolipid of Corynebacterium diphtheriae on mitochondrial structure and function.白喉棒状杆菌一种有毒糖脂对线粒体结构和功能的作用。
J Bacteriol. 1970 Mar;101(3):709-16. doi: 10.1128/jb.101.3.709-716.1970.
2
Site of action of the cord factor of Corynebacterium diphtheriae in mitochondria.白喉棒状杆菌索状因子在线粒体中的作用位点。
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[Mechanism of action of cord factor (trehalose-6,6'-dimycolate) of Mycobacterium tuberculosis].
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Studies of a biochemical lesion in experimental tuberculosis in mice. VII. Structural and functional damage in mouse liver mitochondria under the toxic action of cord factor.
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Synergistic action of cord factor and mycobacterial sulfatides on mitochondria.索状因子与分枝杆菌硫脂对线粒体的协同作用。
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Corynebacterium diphtheriae and its relatives.白喉棒状杆菌及其相关菌。
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Site of action of the cord factor of Corynebacterium diphtheriae in mitochondria.白喉棒状杆菌索状因子在线粒体中的作用位点。
J Bacteriol. 1971 Sep;107(3):746-52. doi: 10.1128/jb.107.3.746-752.1971.
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Highly toxinogenic but avirulent Park-Williams 8 strain of Corynebacterium diphtheriae does not produce siderophore.高产毒素但无毒的白喉棒状杆菌帕克-威廉姆斯8型菌株不产生铁载体。
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Three variants of Corynebacterium diphtheriae subsp. mitis (Belfanti) isolated from a throat specimen.从一份咽喉标本中分离出的轻型白喉棒状杆菌亚种（贝尔凡蒂）的三个变体。
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本文引用的文献

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[The isolation and chemical constitution of a branched hydroxy-acid from Corynebacterium diphtheriae].[从白喉棒状杆菌中分离出一种支链羟基酸及其化学组成]
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Uncoupling of oxidative phosphorylation by cadmium ion.镉离子导致氧化磷酸化解偶联。
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Synthesis of cord factor-active substances.
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[Chemical structure of an unsaturated mycolic acid isolated from Corynebacterium diphtheriae].[从白喉棒状杆菌中分离出的一种不饱和分枝菌酸的化学结构]
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Studies of a biochemical lesion in experimental tuberculosis in mice. XI. Mitochondrial swelling induced by cord factor in vitro.
Am Rev Respir Dis. 1969 Jul;100(1):47-53. doi: 10.1164/arrd.1969.100.1.47.
6
Studies of a biochemical lesion in experimental tuberculosis in mice. VII. Structural and functional damage in mouse liver mitochondria under the toxic action of cord factor.
Am Rev Respir Dis. 1968 Aug;98(2):260-9. doi: 10.1164/arrd.1968.98.2.260.
7
Studies of a biochemical lesion in experimental tuberculosis in mice. 3. Site of lesion in electron transport chain.
Am Rev Respir Dis. 1966 Sep;94(3):388-94. doi: 10.1164/arrd.1966.94.3.388.
8
Studies of a biochemical lesion in experimental tuberculosis in mice. X. Mitochondrial swelling induced by cord factor in vivo and accompanying biochemical change.
Am Rev Respir Dis. 1969 Jul;100(1):42-6. doi: 10.1164/arrd.1969.100.1.42.

白喉棒状杆菌一种有毒糖脂对线粒体结构和功能的作用。

Action of a toxic glycolipid of Corynebacterium diphtheriae on mitochondrial structure and function.

作者信息

Kato M

出版信息

J Bacteriol. 1970 Mar;101(3):709-16. doi: 10.1128/jb.101.3.709-716.1970.

DOI:10.1128/jb.101.3.709-716.1970
PMID:4314542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250382/
Abstract

The toxicity for mice of the cord factor of Cornebacterium diphtheriae, trehalose-6,6'-dicorynomycolate, was studied. The diphtherial cord factor showed a delayed lethal toxicity for mice; the median lethal dose was 120 mug. Mouse liver mitochondria were disrupted in vivo under the toxic action of the diphtherial cord factor into fragments deficient in both respiration and phosphorylation. The site of metabolic defect in the mitochondrial electron transport system was located at the region prior to the level of cytochrome c in the livers of cord factor-intoxicated mice. These effects of the diphtherial cord factor on the host-cell mitochondria were essentially similar to those of the cord factor of Mycobacterium tuberculosis, trehalose-6,6'-dimycolate.

摘要

对白喉棒状杆菌的索状因子海藻糖 -6,6'- 二分枝菌酸对小鼠的毒性进行了研究。白喉索状因子对小鼠呈现出延迟性致死毒性；半数致死剂量为120微克。在白喉索状因子的毒性作用下，小鼠肝脏线粒体在体内被破坏成呼吸和磷酸化均有缺陷的片段。在索状因子中毒小鼠的肝脏中，线粒体电子传递系统的代谢缺陷位点位于细胞色素c水平之前的区域。白喉索状因子对宿主细胞线粒体的这些作用与结核分枝杆菌的索状因子海藻糖 -6,6'- 二霉菌酸的作用基本相似。